Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents

M Mottamal, S Zheng, TL Huang, G Wang - Molecules, 2015 - mdpi.com
Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …

Recent progress in histone deacetylase inhibitors as anticancer agents

L Cappellacci, DR Perinelli, F Maggi… - Current medicinal …, 2020 - ingentaconnect.com
Histone Deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

The search for potent, small‐molecule HDACIs in cancer treatment: a decade after vorinostat

C Zagni, G Floresta, G Monciino… - Medicinal research …, 2017 - Wiley Online Library
Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are
involved in the epigenetic regulation of gene expression. In the last decade, inhibition of …

Histone Deacetylase (HDAC) Inhibitors-emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

S Ahmad Ganai, M Ramadoss… - Current …, 2016 - ingentaconnect.com
Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …

[HTML][HTML] Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from Crocus sativus L. against breast cancer and its binding …

MA Mir, SA Ganai, S Mansoor, S Jan, P Mani… - Saudi Journal of …, 2020 - Elsevier
Saffron plant (Crocus sativus L.) is being used as a source of saffron spice and medicine to
cure or prevent different types of diseases including cancers. We report the isolation …

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors

K Nepali, TY Chang, MJ Lai, KC Hsu, Y Yen… - European Journal of …, 2020 - Elsevier
This study reports the design, synthesis and evaluation of a series of histone deacetylase
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …

In Silico Approaches for Investigating the Binding Propensity of Apigenin and Luteolin Against Class I HDAC Isoforms

SA Ganai, Z Farooq, S Banday… - Future medicinal …, 2018 - Taylor & Francis
Aim: Aberrant activity of class I histone deacetylases (HDACs) has strong implications for
various cancers. Targeting these HDACs with synthetic HDAC inhibitors has shown …

Modelling and enhanced molecular dynamics to steer structure-based drug discovery

S Kalyaanamoorthy, YPP Chen - Progress in biophysics and molecular …, 2014 - Elsevier
The ever-increasing gap between the availabilities of the genome sequences and the crystal
structures of proteins remains one of the significant challenges to the modern drug discovery …

A rational approach for the identification of non-hydroxamate HDAC6-selective inhibitors

L Goracci, N Deschamps, GM Randazzo, C Petit… - Scientific reports, 2016 - nature.com
The human histone deacetylase isoform 6 (HDAC6) has been demonstrated to play a major
role in cell motility and aggresome formation, being interesting for the treatment of multiple …

Combinatorial In Silico Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective …

SA Ganai, E Abdullah, R Rashid… - Frontiers in molecular …, 2017 - frontiersin.org
Histone deacetylases (HDACs) regulate epigenetic gene expression programs by
modulating chromatin architecture and are required for neuronal development …