Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents
M Mottamal, S Zheng, TL Huang, G Wang - Molecules, 2015 - mdpi.com
Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …
histones and regulate expression of tumor suppressor genes. They are implicated in many …
Recent progress in histone deacetylase inhibitors as anticancer agents
Histone Deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …
The search for potent, small‐molecule HDACIs in cancer treatment: a decade after vorinostat
C Zagni, G Floresta, G Monciino… - Medicinal research …, 2017 - Wiley Online Library
Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are
involved in the epigenetic regulation of gene expression. In the last decade, inhibition of …
involved in the epigenetic regulation of gene expression. In the last decade, inhibition of …
Histone Deacetylase (HDAC) Inhibitors-emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration
S Ahmad Ganai, M Ramadoss… - Current …, 2016 - ingentaconnect.com
Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …
transcription programs that govern neuronal memory, plasticity and learning paradigms …
[HTML][HTML] Isolation, purification and characterization of naturally derived Crocetin beta-d-glucosyl ester from Crocus sativus L. against breast cancer and its binding …
Saffron plant (Crocus sativus L.) is being used as a source of saffron spice and medicine to
cure or prevent different types of diseases including cancers. We report the isolation …
cure or prevent different types of diseases including cancers. We report the isolation …
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors
This study reports the design, synthesis and evaluation of a series of histone deacetylase
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …
In Silico Approaches for Investigating the Binding Propensity of Apigenin and Luteolin Against Class I HDAC Isoforms
Aim: Aberrant activity of class I histone deacetylases (HDACs) has strong implications for
various cancers. Targeting these HDACs with synthetic HDAC inhibitors has shown …
various cancers. Targeting these HDACs with synthetic HDAC inhibitors has shown …
Modelling and enhanced molecular dynamics to steer structure-based drug discovery
S Kalyaanamoorthy, YPP Chen - Progress in biophysics and molecular …, 2014 - Elsevier
The ever-increasing gap between the availabilities of the genome sequences and the crystal
structures of proteins remains one of the significant challenges to the modern drug discovery …
structures of proteins remains one of the significant challenges to the modern drug discovery …
A rational approach for the identification of non-hydroxamate HDAC6-selective inhibitors
L Goracci, N Deschamps, GM Randazzo, C Petit… - Scientific reports, 2016 - nature.com
The human histone deacetylase isoform 6 (HDAC6) has been demonstrated to play a major
role in cell motility and aggresome formation, being interesting for the treatment of multiple …
role in cell motility and aggresome formation, being interesting for the treatment of multiple …
Combinatorial In Silico Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective …
Histone deacetylases (HDACs) regulate epigenetic gene expression programs by
modulating chromatin architecture and are required for neuronal development …
modulating chromatin architecture and are required for neuronal development …