Chronic granulomatous disease is a primary immunodeficiency caused by defects in the
structural subunits of the NADPH oxidase. Impaired NADPH oxidase function leads to a …

NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces
superoxide (O2•−), a key reactive oxygen species (ROS) that is essential in innate and …

Phagocyte NADPH oxidase, a protein complex with a core made up of NOX2 and p22
subunits, is responsible for transferring electrons from intracellular NADPH to extracellular …

Chronic granulomatous disease (CGD) is a phagocytic defect characterized by recurrent
bacterial and fungal infections. We report clinical profile of patients with CGD and …

Chronic granulomatous disease (CGD) is a human IEI caused by mutations in genes
encoding the NADPH oxidase subunits, the enzyme responsible for the respiratory burst …

The transmembrane protein p22 phox heterodimerizes with NADPH oxidase (Nox) 1–4 and
is essential for the reactive oxygen species-producing capacity of oxidases. Missense …

p47 phox-deficient chronic granulomatous disease (p47-CGD) is a primary
immunodeficiency caused by mutations in the neutrophil cytosolic factor 1 (NCF1) gene …

Since their description by Metchnikoff in 1905, phagocytes have been increasingly
recognized to be the entities that traffic to sites of infection and inflammation, engulf and kill …

The patient reported here underwent hematopoietic stem cell transplantation (HSCT) due to
chronic granulomatous disease (CGD) caused by biallelic mutations of the NCF1 gene. Two …

Abstract p47 phox-deficient chronic granulomatous disease (p47-CGD) is a primary
immunodeficiency caused by mutations in the neutrophil cytosolic factor 1 (NCF1) gene …