Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm in a process called spermiogenesis. This process is distinct from …

Neuropsychiatric disease frequently presents with an underlying hyporeactivity or
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry …

BACKGROUND: Traumatic experiences in early life are risk factors for the development of
behavioral and emotional disorders. Such disorders can persist through adulthood and have …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …

Both genetic and epigenetic responses of organisms to environmental factors, including
chemical exposures, influence adaptation, susceptibility to toxicity and biodiversity. In model …

Context A disturbed process of gonadal formation and maintenance may result in testicular
dysgenesis syndrome or disorders of sex development (DSDs), with an increased germ cell …

Altered stress reactivity is a predominant feature of posttraumatic stress disorder (PTSD) and
may reflect disease vulnerability, increasing the probability that an individual will develop …

The epigenome is the overall epigenetic state of a cell and represents the ensemble of
chromatin modifications. It is an essential mechanism for the regulation of the genome that …