Abstract Mu-Opioid Receptors (MORs) are well-known for participating in analgesia,
sedation, drug addiction, and other physiological functions. Although MORs have been …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Microglia participates in the modulation of pain signaling. The activation of microglia is
suggested to play an important role in affective disorders that are related to a dysfunction of …

Methods: Here, we aim to evaluate how inflammatory pain affects levels of alcohol drinking
in male and female rats with a history of alcohol. For that, we used an intermittent access 2 …

Excessive alcohol consumption in adolescence can disrupt neural development and may
augment pain perception. Recent studies have shown that the nucleus accumbens (NAc) …

Alcohol consumption leads to significant neurochemical and neurobiological changes,
contributing to the development of alcohol use disorders (AUDs), which exhibit sex-and age …

Abstract Purpose of Review Alcohol use disorder (AUD) and chronic pain are frequently
comorbid conditions. This review aims to communicate recent research describing the …

Alcohol relapse is the treatment target for medications development for alcohol dependence.
Aticaprant, a selective and short-acting kappa-opioid receptor (KOR) antagonist, has …

Pain comorbidities include several psychological disorders, such as anxiety and anhedonia.
However, the way pain affects male and female individuals and by which mechanism is not …

Purpose Alcohol use disorders (AUDs) are influenced by factors that can initiate, maintain,
or induce relapse. Chronic pain has been linked to AUD as both a risk factor and a …