Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, widely used analgesics. For
the past 2 decades, considerable attention has been focused on their cardiovascular safety …

Millions of individuals in the United States require long-term treatment with an oral
anticoagulant. For decades, vitamin K antagonists were the only oral option available; …

Background Four new oral anticoagulants compare favourably with warfarin for stroke
prevention in patients with atrial fibrillation; however, the balance between efficacy and …

Atrial fibrillation (AF) confers a substantial risk of mortality and morbidity from stroke and
thrombo-embolism, and this common cardiac arrhythmia represents a major healthcare …

Vitamin K antagonists (VKAs) have been the standard of care for treatment of
thromboembolic diseases. Target-specific oral anticoagulants (TSOACs) have been …

Abstract The Canadian Cardiovascular Society (CCS) Atrial Fibrillation (AF) Guidelines
Committee provides periodic reviews of new data to produce focused updates that address …

Background Atrial fibrillation is an important cause of morbidity and mortality worldwide, but
scant data are available for long-term outcomes in individuals outside North America or …

Objectives To evaluate the efficacy and safety of new oral anticoagulants (NOAC s) in
elderly adults. Design Meta‐analyses of randomized clinical trials (RCT s). Setting PubMed …

Importance Randomized studies have shown a decreased risk of intracranial hemorrhage
(ICH) with use of novel oral anticoagulants (NOACs). However, it is unclear whether the …

Importance Antithrombotic treatment is indicated for use in patients after myocardial
infarction (MI); however, concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) …