Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Hydrogels have been widely investigated in biomedical fields due to their similar physical
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …

Collagen has shown promise as a bioink for extrusion-based bioprinting, but further
development of new collagen bioink formulations is necessary to improve their printability …

The cells and tissues that make up our body manage contradictory mechanical demands. It
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

In the last few decades, hyaluronic acid (HA) has become increasingly employed as a
biomaterial in both clinical and research applications. The abundance of HA in many …

The extracellular matrix (ECM) is extensively remodeled in tumor tissues. Overproduction of
collagens, pathological collagen crosslinking and alignment of fibers are major processes …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

Glioblastoma multiforme (GBM) is the most common brain tumor with very aggressive and
infiltrative. Extracellular matrix (ECM) plays pivotal roles in the infiltrative characteristics of …

Fibrillar collagen gels, which are used extensively in vitro to study tumor–microenvironment
interactions, are composed of a cell-instructive network of interconnected fibers and pores …