The emergence of next-generation sequencing platforms led to resurgence of research in
whole-genome shotgun assembly algorithms and software. DNA sequencing data from the …

Metagenomics is a discipline that enables the genomic study of uncultured microorganisms.
Faster, cheaper sequencing technologies and the ability to sequence uncultured microbes …

Genome sequence analysis has enabled significant advancements in medical and scientific
areas such as personalized medicine, outbreak tracing, and the understanding of evolution …

Motivation: PacBio single molecule real-time sequencing is a third-generation sequencing
technique producing long reads, with comparatively lower throughput and higher error rate …

Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is
central to global food security. It is clonally propagated, highly heterozygous, autotetraploid …

We have developed a new set of algorithms, collectively called “Velvet,” to manipulate de
Bruijn graphs for genomic sequence assembly. A de Bruijn graph is a compact …

Characterizing the errors generated by common high-throughput sequencing platforms and
telling true genetic variation from technical artefacts are two interdependent steps, essential …

An accurate genome sequence of a desired species is now a pre-requisite for genome
research. An important step in obtaining a high-quality genome sequence is to correctly …

Demand for DNA sequence information has never been greater, yet current Sanger
technology is too costly, time consuming, and labor intensive to meet this ongoing demand …

Lighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids
counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k …