Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Exercise is essential in regulating energy metabolism and whole-body insulin sensitivity. To
explore the exercise signaling network, we undertook a global analysis of protein …

The beneficial effects of regular exercise for the promotion of health and cure of diseases
have been clearly shown. In this review, we would like to postulate the idea that exercise …

The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Patients with type 2 diabetes mellitus suffer from dysregulation of a plethora of
cardiovascular and metabolic functions, including dysglycaemia, dyslipidaemia, arterial …

For decades, exercise has been consid-ered a cornerstone of diabetes management, along
with diet and medication. However, high-quality evidence on the importance of exercise and …

Skeletal muscle adapts to chronic physical activity by inducing mitochondrial biogenesis and
switching proportions of muscle fibers from type II to type I. Several major factors involved in …