Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have
the potential to quickly and reliably sequence the entire human genome for less than $1000 …

The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

Mixed linear model (MLM) methods have proven useful in controlling for population structure
and relatedness within genome-wide association studies. However, MLM-based methods …

Pain sensitivity varies substantially among humans. A significant part of the human
population develops chronic pain conditions that are characterized by heightened pain …

If reward-associated cues acquire the properties of incentive stimuli they can come to
powerfully control behavior, and potentially promote maladaptive behavior. Pavlovian …

While the cause of autism remains unknown, the high concordance between monozygotic
twins supports a strong genetic component. The importance of genetic factors in autism …

The importance of genetic factors in autism has prompted the development of mutant mouse
models to advance our understanding of biological mechanisms underlying autistic …

The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …

Although mitochondrial contributions to cancer have been recognised for approximately a
century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome …

Recombinant inbred (RI) strains are an important resource for mapping complex traits in
many species. While large RI panels are available for Arabidopsis, maize, C. elegans, and …