The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

Traditionally, herbal compounds have been the focus of scientific interest for the last several
centuries, and continuous research into their medicinal potential is underway. Berberine …

Berberine is a plant extract widely used in clinical practice. This review aimed to summarize
and to grade the available evidence on the association between berberine consumption and …

Cancer is the most commonly diagnosed type of disease and a major cause of death
worldwide. Despite advancement in various treatment modules, there has been little …

Macrophages, an important part of human immune system, possess a high plasticity and
heterogeneity (macrophage polarization) as classically activated macrophages (M1) and …

The phytogenous alkaloid berberine (BBR) has become a potential drug for the treatment of
diabetes, hyperlipidemia, and cancer. However, its therapeutic potential is limited because …

Plant diseases caused by pathogenic bacteria and fungi are major threats to both wild plants
and crops. To counteract these threats, plants have evolved various defense mechanisms …

Type-2 diabetes mellitus (T2DM) is one of the most concerning public health problems
because of its high incidence, multiple complications, and difficult treatment. Human islet …

As a natural dietary ingredient, berberine possesses multiple biological activities including
anti-inflammatory effects. In this work, glucocorticoid receptor (GR)-mediated alleviation of …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical
critical diseases with high morbidity and mortality. Especially since the COVID-19 outbreak …