Prion-like propagation of post-translationally modified tau in Alzheimer's disease: a hypothesis
SK Sonawane, S Chinnathambi - Journal of Molecular Neuroscience, 2018 - Springer
The microtubule-associated protein Tau plays a key role in the neuropathology of
Alzheimer's disease by forming intracellular neurofibrillary tangles. Tau in the normal …
Alzheimer's disease by forming intracellular neurofibrillary tangles. Tau in the normal …
Visualization of Protein‐Specific Glycation in Living Cells via Bioorthogonal Chemical Reporter
Z Shao, H Yuan, Z Zhou, Y Wang, P Hou… - Angewandte Chemie …, 2022 - Wiley Online Library
Due to the lack of suitable chemical tools, probing the protein‐specific glycation is highly
challenging. Herein, we present a strategy based on glycation chemical reporter and …
challenging. Herein, we present a strategy based on glycation chemical reporter and …
Sensitive and site-specific identification of carboxymethylated and carboxyethylated peptides in tryptic digests of proteins and human plasma
U Greifenhagen, VD Nguyen, J Moschner… - Journal of Proteome …, 2015 - ACS Publications
Glycation refers to a nonenzymatic post-translational modification formed by the reaction of
amino groups and reducing sugars. Consecutive oxidation and degradation can produce …
amino groups and reducing sugars. Consecutive oxidation and degradation can produce …
Anti-age antibodies for treating inflammation and auto-immune disorders
LS Gruber - US Patent 10,584,180, 2020 - Google Patents
(57) ABSTRACT A composition for treating inflammation or auto-immune disorders
comprises (i) an antibody that binds to an AGE-modified protein on a cell, and (ii) an anti …
comprises (i) an antibody that binds to an AGE-modified protein on a cell, and (ii) an anti …
Humanized monoclonal advanced glycation end-product antibody
LS Gruber - US Patent 10,919,957, 2021 - Google Patents
6,090,382 A 6,176,842 B1 6,245,318 B1 6,309,355 B1 6,380,165 B1 6,387,373 B1
6,410,598 B1 6,670,136 B2 6,676,963 B1 6,818,215 B2 6,821,274 B2 7,033,574 B1 …
6,410,598 B1 6,670,136 B2 6,676,963 B1 6,818,215 B2 6,821,274 B2 7,033,574 B1 …
Product and method for treating sarcopenia
LS Gruber - US Patent 10,358,502, 2019 - Google Patents
A method of treating sarcopenia comprises administering to a subject a composition
comprising an anti-AGE antibody. The method may also be used for preventing or delaying …
comprising an anti-AGE antibody. The method may also be used for preventing or delaying …
Method and composition for treating sarcopenia
LS Gruber - US Patent 11,872,269, 2024 - Google Patents
RRUYWEMUWIRRNB-LURJTMIESA-N (2s)-6-amino-2-[carboxy (methyl) amino] hexanoic
acid Chemical compound OC (= O) N (C)[C@ H](C (O)= O) CCCCN RRUYWEMUWIRRNB …
acid Chemical compound OC (= O) N (C)[C@ H](C (O)= O) CCCCN RRUYWEMUWIRRNB …
Selective removal of cells having accumulated agents
LS Gruber - US Patent 10,960,234, 2021 - Google Patents
6,176,842 B1 6,245,318 B1 6,309,355 B1 6,380,165 B1 6,387,373 B1 6,410,598 B1
6,670,136 B2 6,676,963 B1 6,818,215 B2 6,821,274 B2 7,033,574 B1 7,101,838 B2 …
6,670,136 B2 6,676,963 B1 6,818,215 B2 6,821,274 B2 7,033,574 B1 7,101,838 B2 …
Methods, compositions and apparatuses for facilitating regeneration
LS Gruber - US Patent 11,261,241, 2022 - Google Patents
Forbes, JM et al.,“Below the radar: Advanced glycation end products that detour" around the
side", Clinical Biochemist Reviews vol. 26, pp. 123-134,(2005). Paul, WE,“Fundamental …
side", Clinical Biochemist Reviews vol. 26, pp. 123-134,(2005). Paul, WE,“Fundamental …
Vaccines for use in treating various diseases and disorders
LS Gruber - US Patent 11,213,585, 2022 - Google Patents
(57) ABSTRACT 4,217,344 A 4,900,747 A 4,911,928 A 4,917,951 A 4,965,288 A 5,494,791
A 5,518,720 A 5,601,526 A 5,620,479 A 5,664,570 A 5,693,762 A 5,702,704 A 5,766,590 A …
A 5,518,720 A 5,601,526 A 5,620,479 A 5,664,570 A 5,693,762 A 5,702,704 A 5,766,590 A …