Liver metastases

DI Tsilimigras, P Brodt, PA Clavien… - Nature reviews Disease …, 2021 - nature.com
Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …

Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases …

DI Tsilimigras, I Ntanasis-Stathopoulos, F Bagante… - Surgical oncology, 2018 - Elsevier
Background Hepatic resection is considered the optimal potentially curative treatment for
colorectal liver metastases (CRLM). Following resection, up to two-thirds of patients will …

Long-term oncologic outcomes after laparoscopic versus open resection for colorectal liver metastases: a randomized trial

DL Aghayan, AM Kazaryan, VJ Dagenborg… - Annals of internal …, 2021 - acpjournals.org
Background: Despite the recent worldwide dissemination of laparoscopic liver surgery, no
high-level evidence supports the oncologic safety of this approach. Objective: To evaluate …

Parenchymal-sparing versus anatomic liver resection for colorectal liver metastases: a systematic review

D Moris, S Ronnekleiv-Kelly, AA Rahnemai-Azar… - Journal of …, 2017 - Elsevier
Introduction Colorectal liver metastases develop in 50% of patients diagnosed with
colorectal cancer. Surgical resection for colorectal liver metastasis typically involves either …

Impact of surgical margin width on recurrence and overall survival following R0 hepatic resection of colorectal metastases: a systematic review and meta-analysis

GA Margonis, TN Sergentanis… - Annals of …, 2018 - journals.lww.com
Objective: To examine the impact of surgical margin width on survival following R0 hepatic
resection for colorectal metastases (CRLM). Summary of Background Data: Although …

Anatomical resections improve disease-free survival in patients with KRAS-mutated colorectal liver metastases

GA Margonis, S Buettner, N Andreatos, K Sasaki… - Annals of …, 2017 - journals.lww.com
Objective: To investigate the potential clinical advantage of anatomical resection versus
nonanatomical resection for colorectal liver metastases, according to KRAS mutational …

[HTML][HTML] Colorectal cancer liver metastases: Genomics and biomarkers with focus on local therapies

Y Kitsel, T Cooke, V Sotirchos, CT Sofocleous - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a leading cause of death among cancer
patients, and the liver is the most common visceral metastatic site. Despite promising …

Using artificial intelligence to find the optimal margin width in hepatectomy for colorectal cancer liver metastases

D Bertsimas, GA Margonis, S Sujichantararat… - JAMA …, 2022 - jamanetwork.com
Importance In patients with resectable colorectal cancer liver metastases (CRLM), the choice
of surgical technique and resection margin are the only variables that are under the …

Higher tumor burden status dictates the impact of surgical margin status on overall survival in patients undergoing resection of intrahepatic cholangiocarcinoma

Y Endo, K Sasaki, Z Moazzam, HA Lima… - Annals of Surgical …, 2023 - Springer
Background The present study aimed to examine the prognostic significance of margin
status following hepatectomy of intrahepatic cholangiocarcinoma (ICC) relative to overall …

The prognostic role of lymphovascular invasion and lymph node metastasis in perihilar and intrahepatic cholangiocarcinoma

G Lurje, J Bednarsch, Z Czigany, I Lurje… - European journal of …, 2019 - Elsevier
Introduction Cholangiocellular carcinoma (CCA) is an aggressive malignancy with a dismal
prognosis. Among curative treatment options for CCA, radical surgical resection with …