Lessons in self-defence: inhibition of virus entry by intrinsic immunity
S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
[HTML][HTML] Prevention and treatment of COVID-19: Focus on interferons, chloroquine/hydroxychloroquine, azithromycin, and vaccine
The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has drawn the attention of researchers and clinicians from several disciplines …
(SARS-CoV-2) has drawn the attention of researchers and clinicians from several disciplines …
Interferon-induced transmembrane protein 3 blocks fusion of diverse enveloped viruses by altering mechanical properties of cell membranes
Interferon-induced transmembrane protein 3 (IFITM3) potently inhibits entry of diverse
enveloped viruses by trapping the viral fusion at a hemifusion stage, but the underlying …
enveloped viruses by trapping the viral fusion at a hemifusion stage, but the underlying …
Interferon-induced transmembrane protein (IFITM3) is upregulated explicitly in SARS-CoV-2 infected lung epithelial cells
Current guidelines for COVID-19 management recommend the utilization of various
repurposed drugs. Despite ongoing research toward the development of a vaccine against …
repurposed drugs. Despite ongoing research toward the development of a vaccine against …
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses
M Clement, JL Forbester, M Marsden… - Nature …, 2022 - nature.com
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral
pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human …
pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human …
S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs
Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral
proteins that are active against many viruses, including influenza A virus (IAV), dengue virus …
proteins that are active against many viruses, including influenza A virus (IAV), dengue virus …
Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue
Omicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-
CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread …
CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread …
Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state
The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225
family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells …
family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells …
Functional involvement of interferon-inducible transmembrane proteins in antiviral immunity
Y Liao, MU Goraya, X Yuan, B Zhang, SH Chiu… - Frontiers in …, 2019 - frontiersin.org
Interferons (IFNs) play crucial roles in host defense against viral infections by inducing the
expression of numerous IFN-stimulated genes (ISGs) that can activate host antiviral …
expression of numerous IFN-stimulated genes (ISGs) that can activate host antiviral …
Protein S-palmitoylation in immunity
S-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls
protein activity, stability, trafficking and protein–protein interactions. Recent global profiling …
protein activity, stability, trafficking and protein–protein interactions. Recent global profiling …