Depression is less prevalent among older adults than among younger adults, but it can have
serious consequences. More than half of cases represent a first onset in later life. Although …

Depression is perhaps the most frequent cause of emotional suffering in later life and
significantly decreases quality of life in older adults. In recent years, the literature on late-life …

In elderly people, depression mainly affects those with chronic medical illnesses and
cognitive impairment, causes suffering, family disruption, and disability, worsens the …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

We review the findings in major depression of a low plasma and particularly red cell folate,
but also of low vitamin B12 status. Both low folate and low vitamin B12 status have been …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Background. Despite the burden of depression in late life, its origins present a paradox to
investigators and clinicians alike. Method. We review biological (genetics and heredity …

The authors performed a meta-analysis of studies examining the association between
polymorphisms in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene, including …

Background Hippocampal volume reduction has been reported inconsistently in people with
major depression. Aims To evaluate the interrelationships between hippocampal volumes …

Although cognitive and functional impairment are the hallmark features of Alzheimer's
disease (AD), neuropsychiatric symptoms associated with AD account for increased rates of …