Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …

Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at
various steps of the transcription process. Recent advances highlight the role of nuclear …

The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities.
DDK, in particular, is involved in setting the temporal program of origin activation, a …

DNA unwinding at eukaryotic replication forks displaces parental histones, which must be
redeposited onto nascent DNA in order to preserve chromatin structure. By screening …

During each cell duplication, the entirety of the genomic DNA in every cell must be
accurately and quickly copied. Given the short time available for the chore, the requirement …

Embedded in the nuclear envelope, nuclear pore complexes (NPCs) not only regulate
nuclear transport but also interface with transcriptionally active euchromatin, largely silenced …

Saccharomyces cerevisiae provides a well-studied model system for heritable silent
chromatin in which a histone-binding protein complex [the SIR (silent information regulator) …

Telomeres form the ends of linear chromosomes and protect these ends from being
recognized as DNA double-strand breaks. Telomeric sequences are maintained in most …