Uncovering the Hidden Credentials of Brucella Virulence

RM Roop, IS Barton, D Hopersberger… - … and Molecular Biology …, 2021 - Am Soc Microbiol
Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Internal affairs: investigating the Brucella intracellular lifestyle

K von Bargen, JP Gorvel… - FEMS microbiology …, 2012 - academic.oup.com
Bacteria of the genus Brucella are Gram-negative pathogens of several animal species that
cause a zoonotic disease in humans known as brucellosis or Malta fever. Within their hosts …

[HTML][HTML] Cell-mediated immunity in human brucellosis

P Skendros, G Pappas, P Boura - Microbes and infection, 2011 - Elsevier
Brucella can parasitize within human antigen-presenting cells modifying phagocytosis,
phagolysosome fusion, antigen presentation, cytokine secretion, and apoptosis. Subversion …

When the Going Gets Rough: The Significance of Brucella Lipopolysaccharide Phenotype in Host–Pathogen Interactions

LW Stranahan, AM Arenas-Gamboa - Frontiers in Microbiology, 2021 - frontiersin.org
Brucella is a facultatively intracellular bacterial pathogen and the cause of worldwide
zoonotic infections, infamous for its ability to evade the immune system and persist …

Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice

ED Avila-Calderón, A Lopez-Merino… - Journal of …, 2012 - Wiley Online Library
The outer membrane vesicles (OMVs) from smooth B. melitensis 16 M and a derived rough
mutant, VTRM1 strain, were purified and characterized with respect to protein content and …

TLR2 and TLR4 signaling pathways are required for recombinant Brucella abortus BCSP31-induced cytokine production, functional upregulation of mouse …

JY Li, Y Liu, XX Gao, X Gao, H Cai - Cellular & molecular immunology, 2014 - nature.com
Brucella abortus is a zoonotic Gram-negative pathogen that causes brucelosis in ruminants
and humans. Toll-like receptors (TLRs) recognize Brucella abortus and initiate antigen …

[HTML][HTML] Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis

CG Samartino, MV Delpino, CP Godoy… - The American journal of …, 2010 - Elsevier
Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an
inflammatory disorder called neurobrucellosis. In this study we present in vivo and in vitro …

Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases

R Scian, P Barrionuevo, GH Giambartolomei… - Infection and …, 2011 - Am Soc Microbiol
Arthritis is one of the most common complications of human brucellosis, but its pathogenic
mechanisms have not been elucidated. Fibroblast-like synoviocytes (FLS) are known to be …

Cell and Tissue Tropism of Brucella spp.

TP Carvalho, LA Silva, TLL Castanheira… - Infection and …, 2023 - Am Soc Microbiol
Brucella spp. are facultatively intracellular bacteria that can infect, survive, and multiply in
various host cell types in vivo and/or in vitro. The genus Brucella has markedly expanded in …

Immunosuppressive mechanisms in brucellosis in light of chronic bacterial diseases

JM Pellegrini, JP Gorvel, S Mémet - Microorganisms, 2022 - mdpi.com
Brucellosis is considered one of the major zoonoses worldwide, constituting a critical
livestock and human health concern with a huge socio-economic burden. Brucella genus, its …