Background: Cigarette smoking is the main cause of preventable death in developed
countries. While the direct positive behavioral reinforcing effect of nicotine has historically …

As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …

We suggested recently that attention can be understood as inferring the level of uncertainty
or precision during hierarchical perception. In this paper, we try to substantiate this claim …

Rationale and objective Empirical studies indicate that nicotine enhances some aspects of
attention and cognition, suggesting a role in the maintenance of tobacco dependence. The …

Acetylcholine (ACh) is a neuromodulatory transmitter implicated in perception and learning
under uncertainty. This study combined computational simulations and pharmaco …

Substantial evidence demonstrates both nicotine's addiction liability and its cognition-
enhancing effects. However, the neurobiological mechanisms underlying nicotine's impact …

Evidence from lesion and cortical-slice studies implicate the neocortical cholinergic system
in the modulation of sensory, attentional and memory processing. In this review we consider …

The right temporoparietal junction (rTPJ) has been associated with the ability to reorient
attention to unexpected stimuli and the capacity to understand others' mental states (theory …

Rationale Nicotine has been shown to improve both memory and attention when assessed
through speeded motor responses. Since very few studies have assessed effects of nicotine …

Using 24 h of total sleep deprivation to perturb normal cognitive function, we conducted a
double-blind, placebo-controlled crossover study to evaluate the effect of the …