We assess the current and describe possible future public health impacts of the legalisation
of cannabis production, sale, and use in the Americas. First, we describe global patterns of …

In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

Importance Laws and attitudes toward marijuana in the United States are becoming more
permissive but little is known about whether the prevalence rates of marijuana use and …

Objective: Attitudes toward marijuana are changing, the prevalence of DSM-IV cannabis use
disorder has increased, and DSM-5 modified the cannabis use disorder criteria. Therefore …

Importance Over the last 25 years, illicit cannabis use and cannabis use disorders have
increased among US adults, and 28 states have passed medical marijuana laws (MML) …

Background Cannabis use disorder is the most commonly reported illegal substance use
disorder in the general population; although demand for assistance from health services is …

Substance use is a major cause of disability globally. This has been recognized in the recent
United Nations Sustainable Development Goals (SDGs), in which treatment coverage for …

Importance Cannabis withdrawal syndrome (CWS)—a diagnostic indicator of cannabis use
disorder—commonly occurs on cessation of heavy and prolonged cannabis use. To date …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

Cannabis is the most commonly used illicit substance in the United States. Rates of
cannabis use and cannabis use disorder (CUD) have increased in the past decade …