Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in
several biological processes, including oxygen transport, energy production and drug …

The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the
aging of population. Although the molecular mechanisms leading to neurodegeneration are …

Autism Spectrum Disorders (ASD) is a severe childhood psychiatric condition with an array
of cognitive, language and social impairments that can significantly impact family life. ASD is …

Increased brain iron concentration is often reported concurrently with disease development
in multiple sclerosis (MS) and other neurodegenerative diseases. However, it is unclear …

Amyotrophic lateral sclerosis (ALS) is a progressive and devastating multifactorial
neurodegenerative disorder. Although the pathogenesis of ALS is still not completely …

Heme (iron-protoporphyrin IX) is an essential co-factor involved in several biological
processes, including neuronal survival and differentiation. Nevertheless, an excess of free …

It is widely recognized that Alzheimer's disease (AD) is a common type of progressive
neurodegenerative disorder that results in cognitive impairment over time. Approximately …

Parkinson's disease (PD) is a neurodegenerative disorder that results from the degeneration
of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Since there are only …

Disease models of neurodegeneration with brain iron accumulation (NBIA) offer the
possibility to explore the relationship between iron dyshomeostasis and neurodegeneration …