This article discusses the methods most commonly employed in the analysis of the
triacylglycerols (TAGs) in natural fats and considers the main advantages and …

Hepatic metabolic derangements are key components in the development of fatty liver,
insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is …

To determine the mechanism of the cardiac dilatation and reduced contractility of obese
Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and …

Recent experimental data suggest that adiposity directly damages the heart by promoting
ectopic deposition of triglyceride, a process known as myocardial steatosis. The goal of this …

High concentrations of glucose induce β cell production of IL-1β, leading to impaired β cell
function and apoptosis in human pancreatic islets. IL-1 receptor antagonist (IL-1Ra) is a …

Cross-sectional studies in human subjects have used 1H magnetic resonance spectroscopy
(HMRS) to demonstrate that insulin resistance correlates more tightly with the …

To test the hypothesis that the physiologic liporegulatory role of hyperleptinemia is to
prevent steatosis during caloric excess, we induced obesity by feeding normal Harlan …

Obesity is associated with both insulin resistance and hyperinsulinemia. Initially
hyperinsulinemia compensates for the insulin resistance and thereby maintains normal …

A relationship between increased lipid concentration in the liver and reduced hepatic
function has been suggested; however, there is little direct evidence of change in specific …

Conventional treatment of obesity reduces fat in mature adipocytes but leaves them with
lipogenic enzymes capable of rapid resynthesis of fat, a likely factor in treatment failure …