Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products

M Ibrahim, E Ramadan, NE Elsadek, SE Emam… - Journal of Controlled …, 2022 - Elsevier
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …

Recent developments in the immunopathology of COVID‐19

H Zhang, Y Sun, Y Wang, D Yazici, D Azkur, I Ogulur… - Allergy, 2023 - Wiley Online Library
There has been an important change in the clinical characteristics and immune profile of
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …

[PDF][PDF] Drug allergy: a 2022 practice parameter update

DA Khan, A Banerji, KG Blumenthal, EJ Phillips… - Journal of Allergy and …, 2022 - Elsevier
Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: evidence for immunogenicity of PEG

GT Kozma, T Mészáros, P Berényi, R Facskó, Z Patkó… - Vaccine, 2023 - Elsevier
A small fraction of recipients who receive polyethylene-glycol (PEG)-containing COVID-19
mRNA-LNP vaccines (Comirnaty and Spikevax) develop hypersensitivity reactions (HSRs) …

Safety of COVID-19 vaccination in patients with polyethylene glycol allergy: a case series

M Picard, JP Drolet, MS Masse, CA Filion… - The Journal of …, 2022 - jaci-inpractice.org
Polyethylene glycol (PEG) allergy is generally considered a contraindication to mRNA
coronavirus disease 2019 (COVID-19) vaccines because they are formulated in lipid …

Allergic reactions to COVID-19 vaccines: risk factors, frequency, mechanisms and management

N Luxi, A Giovanazzi, A Arcolaci, P Bonadonna… - BioDrugs, 2022 - Springer
Conventional vaccines have been widely studied, along with their risk of causing allergic
reactions. These generally consist of mild local reactions and only rarely severe …

An update in COVID-19 vaccine reactions in 2023: progress and understanding

KG Blumenthal, M Greenhawt, EJ Phillips… - The Journal of Allergy …, 2023 - Elsevier
It has been 3 years since the coronavirus disease 2019 (COVID-19) pandemic was initially
declared, and 2 years have passed since the first COVID-19 vaccines were introduced …

Diagnostic accuracy of vaccine and vaccine excipient testing in the setting of allergic reactions to COVID‐19 vaccines: a systematic review and meta‐analysis

M Greenhawt, M Shaker, DBK Golden, EM Abrams… - Allergy, 2023 - Wiley Online Library
For persons with immediate allergic reactions to mRNA COVID‐19 vaccines, skin testing
(ST) to the vaccine/excipients (polyethylene glycol [PEG] and polysorbate 80 [PS]) has been …

Risk of second allergic reaction to SARS-CoV-2 vaccines: a systematic review and meta-analysis

DK Chu, EM Abrams, DBK Golden… - JAMA internal …, 2022 - jamanetwork.com
Importance Vaccination against SARS-CoV-2 is a highly effective strategy to prevent
infection and severe COVID-19 outcomes. The best strategy for a second dose of vaccine …

Delayed systemic urticarial reactions following mRNA COVID-19 vaccination

MM Pitlick, AY Joshi… - Allergy and Asthma …, 2022 - ingentaconnect.com
Background: As the vaccination campaign in response to the coronavirus disease 2019
(COVID-19) pandemic continues, concerns with regard to adverse reactions to the vaccine …