Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies
S Shetty, CM Kusminski, PE Scherer - Trends in pharmacological sciences, 2009 - cell.com
Adiponectin is a secretory protein predominantly expressed by adipocytes and released at a
high rate into circulation. The ease with which the levels of adiponectin can be measured …
high rate into circulation. The ease with which the levels of adiponectin can be measured …
Genetic variants and the metabolic syndrome: a systematic review
CM Povel, JMA Boer, E Reiling… - Obesity …, 2011 - Wiley Online Library
Several candidate gene studies on the metabolic syndrome (MetS) have been conducted.
However, for most single nucleotide polymorphisms (SNPs) no systematic review on their …
However, for most single nucleotide polymorphisms (SNPs) no systematic review on their …
Instrumental variables estimation with some invalid instruments and its application to Mendelian randomization
Instrumental variables have been widely used for estimating the causal effect between
exposure and outcome. Conventional estimation methods require complete knowledge …
exposure and outcome. Conventional estimation methods require complete knowledge …
Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study
N Siitonen, L Pulkkinen, J Lindström… - BMC medical …, 2011 - Springer
Background Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-
sensitising and anti-atherogenic effects. Human adiponectin is encoded by the ADIPOQ …
sensitising and anti-atherogenic effects. Human adiponectin is encoded by the ADIPOQ …
Pathomechanisms of type 2 diabetes genes
H Staiger, F Machicao, A Fritsche… - Endocrine …, 2009 - academic.oup.com
Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance
and β-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and …
and β-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and …
Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study
N Mattsson, T Rönnemaa, M Juonala… - Annals of …, 2008 - Taylor & Francis
Background. Obese youths may be susceptible to develop the metabolic syndrome (MS)
later in life. Aim. To study childhood predictors of MS in adulthood. Method. Prospective …
later in life. Aim. To study childhood predictors of MS in adulthood. Method. Prospective …
Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta‐analysis
Z Yu, S Han, X Cao, C Zhu, X Wang, X Guo - Obesity, 2012 - Wiley Online Library
Polymorphisms in adipokine genes, such as leptin (LEP), leptin receptor (LEPR), resistin
(RETN), adiponectin (ADIPOQ), interleukin‐1β (IL‐1β), IL‐6 (IL‐6), and tumor necrosis factor …
(RETN), adiponectin (ADIPOQ), interleukin‐1β (IL‐1β), IL‐6 (IL‐6), and tumor necrosis factor …
Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis
Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues
to grow worldwide. Nutrients and dietary patterns are central issues in the prevention …
to grow worldwide. Nutrients and dietary patterns are central issues in the prevention …
Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond
JY Lu, KC Huang, LC Chang, YS Huang… - Journal of biomedical …, 2008 - Springer
Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of
adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many …
adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many …
Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors
JT Heiker, D Kosel, AG Beck-Sickinger - 2010 - degruyter.com
The adipocytokine adiponectin and its receptor (AdipoR) comprise a new receptor-ligand
system that is involved in a variety of clinically important morbidities such as obesity, type 2 …
system that is involved in a variety of clinically important morbidities such as obesity, type 2 …