Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies

S Shetty, CM Kusminski, PE Scherer - Trends in pharmacological sciences, 2009 - cell.com
Adiponectin is a secretory protein predominantly expressed by adipocytes and released at a
high rate into circulation. The ease with which the levels of adiponectin can be measured …

Genetic variants and the metabolic syndrome: a systematic review

CM Povel, JMA Boer, E Reiling… - Obesity …, 2011 - Wiley Online Library
Several candidate gene studies on the metabolic syndrome (MetS) have been conducted.
However, for most single nucleotide polymorphisms (SNPs) no systematic review on their …

Instrumental variables estimation with some invalid instruments and its application to Mendelian randomization

H Kang, A Zhang, TT Cai, DS Small - Journal of the American …, 2016 - Taylor & Francis
Instrumental variables have been widely used for estimating the causal effect between
exposure and outcome. Conventional estimation methods require complete knowledge …

Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study

N Siitonen, L Pulkkinen, J Lindström… - BMC medical …, 2011 - Springer
Background Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-
sensitising and anti-atherogenic effects. Human adiponectin is encoded by the ADIPOQ …

Pathomechanisms of type 2 diabetes genes

H Staiger, F Machicao, A Fritsche… - Endocrine …, 2009 - academic.oup.com
Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance
and β-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and …

Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study

N Mattsson, T Rönnemaa, M Juonala… - Annals of …, 2008 - Taylor & Francis
Background. Obese youths may be susceptible to develop the metabolic syndrome (MS)
later in life. Aim. To study childhood predictors of MS in adulthood. Method. Prospective …

Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta‐analysis

Z Yu, S Han, X Cao, C Zhu, X Wang, X Guo - Obesity, 2012 - Wiley Online Library
Polymorphisms in adipokine genes, such as leptin (LEP), leptin receptor (LEPR), resistin
(RETN), adiponectin (ADIPOQ), interleukin‐1β (IL‐1β), IL‐6 (IL‐6), and tumor necrosis factor …

Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis

G Berná, MJ Oliveras-López, E Jurado-Ruíz, J Tejedo… - Nutrients, 2014 - mdpi.com
Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues
to grow worldwide. Nutrients and dietary patterns are central issues in the prevention …

Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond

JY Lu, KC Huang, LC Chang, YS Huang… - Journal of biomedical …, 2008 - Springer
Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of
adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many …

Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors

JT Heiker, D Kosel, AG Beck-Sickinger - 2010 - degruyter.com
The adipocytokine adiponectin and its receptor (AdipoR) comprise a new receptor-ligand
system that is involved in a variety of clinically important morbidities such as obesity, type 2 …