[HTML][HTML] A review of 3D-printing of microneedles

M Olowe, SK Parupelli, S Desai - Pharmaceutics, 2022 - mdpi.com
Microneedles are micron-sized devices that are used for the transdermal administration of a
wide range of active pharmaceutics substances with minimally invasive pain. In the past …

Progress and perspective of microneedle system for anti-cancer drug delivery

D Li, D Hu, H Xu, HK Patra, X Liu, Z Zhou, J Tang… - Biomaterials, 2021 - Elsevier
Transdermal drug delivery exhibited encouraging prospects, especially through superficial
drug administration routes. However, only a few limited lipophilic drug molecules could …

[HTML][HTML] A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery

C Yeung, S Chen, B King, H Lin, K King, F Akhtar… - …, 2019 - pubs.aip.org
Embedding microfluidic architectures with microneedles enables fluid management
capabilities that present new degrees of freedom for transdermal drug delivery. To this end …

[HTML][HTML] Dissolving microneedle patches for dermal vaccination

M Leone, J Mönkäre, JA Bouwstra, G Kersten - Pharmaceutical research, 2017 - Springer
The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility
and a dense network of immune cells in the skin. The development of microneedles is …

Microneedle arrays for drug delivery and diagnostics: toward an optimized design, reliable insertion, and penetration

V Ebrahiminejad, PD Prewett… - Advanced Materials …, 2022 - Wiley Online Library
In the past two decades, microneedles have been extensively studied for transdermal
delivery of drug or vaccines and for bio‐fluid extraction. Microneedle‐based devices consist …

Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis

EZ Loizidou, NT Inoue, J Ashton-Barnett… - European Journal of …, 2016 - Elsevier
Computerized tomography scan (CT scan) imaging and finite element analysis were
employed to investigate how the geometric composition of microneedles affects their …

Effect of humidity on mechanical properties of dissolving microneedles for transdermal drug delivery

QL Wang, JW Ren, BZ Chen, X Jin, CY Zhang… - Journal of industrial and …, 2018 - Elsevier
Dissolving microneedles (DMNs) prepared from soluble polymers has been being widely
investigated as a safe and effective transdermal delivery system for drug and vaccine …

[HTML][HTML] Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an …

AM de Groot, G Du, J Mönkäre, ACM Platteel… - Journal of Controlled …, 2017 - Elsevier
The skin is an attractive organ for immunization due to the presence of a large number of
epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and …

Microneedle arrays for vaccine delivery: the possibilities, challenges and use of nanoparticles as a combinatorial approach for enhanced vaccine immunogenicity

AM Rodgers, AS Cordeiro… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Vaccination is one of the greatest breakthroughs of modern preventative
medicine. Despite this, there remain problems surrounding delivery, efficacy and …

[HTML][HTML] Potential of microneedle systems for COVID-19 vaccination: current trends and challenges

J Hassan, C Haigh, T Ahmed, MJ Uddin, DB Das - Pharmaceutics, 2022 - mdpi.com
To prevent the coronavirus disease 2019 (COVID-19) pandemic and aid restoration to
prepandemic normality, global mass vaccination is urgently needed. Inducing herd immunity …