Mechanisms of melanocyte death in vitiligo

J Chen, S Li, C Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Regulatory T cells in vitiligo: implications for pathogenesis and therapeutics

M Dwivedi, EH Kemp, NC Laddha, MS Mansuri… - Autoimmunity …, 2015 - Elsevier
Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in
immunological self-tolerance, which leads to aberrant immune responses against …

CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo

M Rashighi, P Agarwal, JM Richmond… - Science translational …, 2014 - science.org
Vitiligo is an autoimmune disease of the skin that results in disfiguring white spots. There are
no US Food and Drug Administration–approved treatments for vitiligo, and most off-label …

[HTML][HTML] Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress response: a possible mechanism for melanocyte …

Z Jian, K Li, P Song, G Zhu, L Zhu, T Cui, B Liu… - Journal of Investigative …, 2014 - Elsevier
Vitiligo melanocytes possess higher susceptibility to oxidative insults. Consistent with this,
impairment of the antioxidant defense system has been reported to be involved in the onset …

The role of IL-17 in vitiligo: A review

RK Singh, KM Lee, I Vujkovic-Cvijin, D Ucmak… - Autoimmunity …, 2016 - Elsevier
IL-17 is involved in the pathogenesis of several autoimmune diseases; however its role in
vitiligo has not been well defined. Emerging human and mouse studies have demonstrated …

Vitiligo skin T cells are prone to produce type 1 and type 2 cytokines to induce melanocyte dysfunction and epidermal inflammatory response through Jak signaling

C Martins, L Migayron, C Drullion, C Jacquemin… - Journal of Investigative …, 2022 - Elsevier
Vitiligo is a T cell–mediated inflammatory skin disorder characterized by the loss of
epidermal melanocytes. However, the contribution of melanocytes to the physiopathology of …

The many faces of interleukin‐17 in inflammatory skin diseases

R Speeckaert, J Lambert, L Grine… - British Journal of …, 2016 - academic.oup.com
Summary Interleukin (IL)‐17 is an emerging target for inflammatory skin disorders. Given the
remarkable success of its therapeutic inhibition in psoriasis, the pathogenic role of this …

Predominant role of innate pro-inflammatory cytokines in vitiligo disease

N Gholijani, MR Yazdani, L Dastgheib - Archives of dermatological …, 2020 - Springer
Vitiligo is a skin disorder with melanocyte destruction and an autoimmune basis. Given the
importance of cytokines in autoimmunity, we aimed to find the cytokine profile of innate and …

Oxidative stress and immune system in vitiligo and thyroid diseases

R Colucci, F Dragoni, S Moretti - Oxidative medicine and …, 2015 - Wiley Online Library
Vitiligo is an acquired dermatological disease frequently associated with autoimmune
thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo …

Vitiligo-part 1

RG Tarlé, LM Nascimento, MT Mira… - Anais brasileiros de …, 2014 - SciELO Brasil
Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects
melanocytes from epidermis basal layer, leading to the development of hypochromic and …