Recent developments in bioprocessing of recombinant proteins: expression hosts and process development

NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

Platforms for production of protein-based vaccines: from classical to next-generation strategies

R Cid, J Bolívar - Biomolecules, 2021 - mdpi.com
To date, vaccination has become one of the most effective strategies to control and reduce
infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were …

Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine

J Fan, S Kitajima, T Watanabe, J Xu, J Zhang… - Pharmacology & …, 2015 - Elsevier
Laboratory animal models play an important role in the study of human diseases. Using
appropriate animals is critical not only for basic research but also for the development of …

[PDF][PDF] An overview of heterologous expression host systems for the production of recombinant proteins

AR Gomes, SM Byregowda, BM Veeregowda… - Adv. Anim. Vet …, 2016 - academia.edu
With the advent of recombinant DNA technology, cloning and expression of numerous
mammalian genes in different systems have been explored to produce many therapeutics …

The transgenic animal platform for biopharmaceutical production

LR Bertolini, H Meade, CR Lazzarotto, LT Martins… - Transgenic …, 2016 - Springer
The recombinant production of therapeutic proteins for human diseases is currently the
largest source of innovation in the pharmaceutical industry. The market growth has been the …

Extranuclear inheritance of mitochondrial genome and epigenetic reprogrammability of chromosomal telomeres in somatic cell cloning of mammals

M Samiec, M Skrzyszowska - International Journal of Molecular Sciences, 2021 - mdpi.com
The effectiveness of somatic cell nuclear transfer (SCNT) in mammals seems to be still
characterized by the disappointingly low rates of cloned embryos, fetuses, and progeny …

Non-conventional expression systems for the production of vaccine proteins and immunotherapeutic molecules

I Legastelois, S Buffin, I Peubez, C Mignon… - Human vaccines & …, 2017 - Taylor & Francis
The increasing demand for recombinant vaccine antigens or immunotherapeutic molecules
calls into question the universality of current protein expression systems. Vaccine production …

Application of genetically engineered pigs in biomedical research

M Hryhorowicz, D Lipiński, S Hryhorowicz… - Genes, 2020 - mdpi.com
Progress in genetic engineering over the past few decades has made it possible to develop
methods that have led to the production of transgenic animals. The development of …

Goats producing biosimilar human lactoferrin

DM Bogdanovich, VF Radchikov… - … Series: Earth and …, 2021 - iopscience.iop.org
Herd of goats producing biosimilar human lactoferrin has been created. The nature of
transmission of the transgene through a number of generations, productivity according to …

Current approaches and applications in avian genome editing

J Lee, DH Kim, K Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Advances in genome-editing technologies and sequencing of animal genomes enable
researchers to generate genome-edited (GE) livestock as valuable animal models that …