Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

The ability of human tissue to reorganize and restore its existing structure underlies tissue
homeostasis in the healthy airways, but in disease can persist without normal resolution …

Background We previously showed in patients with poorly controlled eosinophilic asthma
that a single dose of benralizumab resulted in significantly improved Asthma Control …

Introduction: The co-presence of bronchiectasis (BE) in severe eosinophilic asthma (SEA) is
common. Data about the effectiveness of benralizumab in patients with SEA and BE (SEA+ …

Biologic therapies in asthma are indicated in severe disease, and they are directed against
specific inflammatory modulators that contribute to pathogenesis and severity. Currently …

The need for airway imaging is defined by the limited sensitivity of common clinical tests like
spirometry, lung diffusion (DLCO) and blood gas analysis to early changes of peripheral …

Airway mucus is a hydrogel with unique biophysical properties due to its primary water
composition and a small proportion of large anionic glycoproteins or mucins. The …

Purpose To determine if proton (1H) MRI–derived specific ventilation is responsive to
bronchodilator (BD) therapy and associated with clinical biomarkers of type 2 airway …

Purpose: The purpose of this study was to anatomically correlate ventilation defects with
regions of air trapping by whole lung, lung lobe, and airway segment in the context of airway …

Airway remodeling (AR) with chronic inflammation, are key features in asthma pathogenesis.
AR characterized by structural changes in the bronchial wall is associated with a specific …