Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products
SM Shen, G Appendino, YW Guo - Natural Product Reports, 2022 - pubs.rsc.org
Covering: July 2010 to August 2021 This article summarizes more than 200 cases of
misassigned marine natural products reported between July 2010 and August 2021, sorting …
misassigned marine natural products reported between July 2010 and August 2021, sorting …
Marine cyclic peptides: Antimicrobial activity and synthetic strategies
R Ribeiro, E Pinto, C Fernandes, E Sousa - Marine Drugs, 2022 - mdpi.com
Oceans are a rich source of structurally unique bioactive compounds from the perspective of
potential therapeutic agents. Marine peptides are a particularly interesting group of …
potential therapeutic agents. Marine peptides are a particularly interesting group of …
Natural cyclopeptides as anticancer agents in the last 20 years
JN Zhang, YX Xia, HJ Zhang - International Journal of Molecular Sciences, 2021 - mdpi.com
Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …
acids. A large number of natural cyclopeptides have been reported to be highly effective …
Total synthesis of apratoxin A and B using Matteson's homologation approach
O Andler, U Kazmaier - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Apratoxin A and B, two members of an interesting class of marine cyclodepsipeptides are
synthesized in a straightforward manner via Matteson homologation. Starting from a chiral …
synthesized in a straightforward manner via Matteson homologation. Starting from a chiral …
Recent advances in polypeptide antibiotics derived from marine microorganisms
W Wang, L Gu, J Wang, X Hu, B Wei, H Zhang, H Wang… - Marine Drugs, 2023 - mdpi.com
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of
available antibiotics are triggering a new health-care crisis. The discovery of novel and …
available antibiotics are triggering a new health-care crisis. The discovery of novel and …
Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.
A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-
derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of …
derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of …
Potent bactericidal antimycobacterials targeting the chaperone ClpC1 based on the depsipeptide natural products ecumicin and ohmyungsamycin A
PME Hawkins, DM Hoi, CY Cheung… - Journal of medicinal …, 2022 - ACS Publications
Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural
products that possess activity against Mycobacterium tuberculosis (Mtb), the causative agent …
products that possess activity against Mycobacterium tuberculosis (Mtb), the causative agent …
Antitumor activity of ohmyungsamycin A through the regulation of the Skp2-p27 axis and MCM4 in human colorectal cancer cells
Ohmyungsamycin A (1), a novel cyclic peptide discovered from a marine Streptomyces sp.,
was previously reported with antibacterial and anticancer activities. However, the antitumor …
was previously reported with antibacterial and anticancer activities. However, the antitumor …
[PDF][PDF] Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions
The biological processes related to protein homeostasis in Mycobacterium tuberculosis, the
etiologic agent of tuberculosis, have recently been established as critical pathways for …
etiologic agent of tuberculosis, have recently been established as critical pathways for …
The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single
infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to …
infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to …