Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products

SM Shen, G Appendino, YW Guo - Natural Product Reports, 2022 - pubs.rsc.org
Covering: July 2010 to August 2021 This article summarizes more than 200 cases of
misassigned marine natural products reported between July 2010 and August 2021, sorting …

Marine cyclic peptides: Antimicrobial activity and synthetic strategies

R Ribeiro, E Pinto, C Fernandes, E Sousa - Marine Drugs, 2022 - mdpi.com
Oceans are a rich source of structurally unique bioactive compounds from the perspective of
potential therapeutic agents. Marine peptides are a particularly interesting group of …

Natural cyclopeptides as anticancer agents in the last 20 years

JN Zhang, YX Xia, HJ Zhang - International Journal of Molecular Sciences, 2021 - mdpi.com
Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …

Total synthesis of apratoxin A and B using Matteson's homologation approach

O Andler, U Kazmaier - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Apratoxin A and B, two members of an interesting class of marine cyclodepsipeptides are
synthesized in a straightforward manner via Matteson homologation. Starting from a chiral …

Recent advances in polypeptide antibiotics derived from marine microorganisms

W Wang, L Gu, J Wang, X Hu, B Wei, H Zhang, H Wang… - Marine Drugs, 2023 - mdpi.com
In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of
available antibiotics are triggering a new health-care crisis. The discovery of novel and …

Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.

JS An, MS Kim, J Han, SC Jang, JH Im… - Journal of Natural …, 2022 - ACS Publications
A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-
derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of …

Potent bactericidal antimycobacterials targeting the chaperone ClpC1 based on the depsipeptide natural products ecumicin and ohmyungsamycin A

PME Hawkins, DM Hoi, CY Cheung… - Journal of medicinal …, 2022 - ACS Publications
Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural
products that possess activity against Mycobacterium tuberculosis (Mtb), the causative agent …

Antitumor activity of ohmyungsamycin A through the regulation of the Skp2-p27 axis and MCM4 in human colorectal cancer cells

WS Byun, S Kim, YH Shin, WK Kim… - Journal of natural …, 2020 - ACS Publications
Ohmyungsamycin A (1), a novel cyclic peptide discovered from a marine Streptomyces sp.,
was previously reported with antibacterial and anticancer activities. However, the antitumor …

[PDF][PDF] Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions

NM Wolf, H Lee, D Zagal, JW Nam, DC Oh… - … Section D: Structural …, 2020 - journals.iucr.org
The biological processes related to protein homeostasis in Mycobacterium tuberculosis, the
etiologic agent of tuberculosis, have recently been established as critical pathways for …

The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles

HI Boshoff, N Malhotra, CE Barry III, S Oh - Pharmaceuticals, 2024 - mdpi.com
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single
infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to …