New approaches in the management of sudden cardiac death in patients with heart failure—targeting the sympathetic nervous system

MG Kiuchi, JM Nolde, H Villacorta… - International Journal of …, 2019 - mdpi.com
Cardiovascular diseases (CVDs) have been considered the most predominant cause of
death and one of the most critical public health issues worldwide. In the past two decades …

Muscle sympathetic activity in resting and exercising humans with and without heart failure

CF Notarius, PJ Millar, JS Floras - Applied Physiology, Nutrition …, 2015 - cdnsciencepub.com
The sympathetic nervous system is critical for coordinating the cardiovascular response to
various types of physical exercise. In a number of disease states, including human heart …

SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease–2023

JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
SciELO - Brazil - Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas–2023

JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
A DC (tripanossomíase americana) é entidade mórbida transmissível, potencialmente fatal,
causada pelo protozoário parasita T. cruzi e que integra o grupo de doenças tropicais …

Sympathetic neural overdrive in congestive heart failure and its correlates: systematic reviews and meta-analysis

G Grassi, G D'Arrigo, A Pisano, D Bolignano… - Journal of …, 2019 - journals.lww.com
Methods: Assessment was extended to the relationships of MSNA with venous plasma
norepinephrine, heart rate (HR) and echocardiographic parameters of cardiac morphology …

Divergent muscle sympathetic responses to dynamic leg exercise in heart failure and age‐matched healthy subjects

CF Notarius, PJ Millar, H Murai, BL Morris… - The Journal of …, 2015 - Wiley Online Library
Key points People with diminished ventricular contraction who develop heart failure have
higher sympathetic nerve firing rates at rest compared with healthy individuals of a similar …

Heart failure-specific inverse relationship between the muscle sympathetic response to dynamic leg exercise and O2peak

DA Keir, CF Notarius, MB Badrov… - Applied Physiology …, 2021 - cdnsciencepub.com
During 1-leg cycling, contralateral muscle sympathetic nerve activity (MSNA) falls in healthy
adults but increases in most with reduced ejection fraction heart failure (HFrEF). We …

Efficacy and safety of exercise rehabilitation for heart failure patients with cardiac resynchronization therapy: a systematic review and meta-analysis

L Ye, S Wang, L Wang - Frontiers in Physiology, 2020 - frontiersin.org
Background: Many heart failure (HF) patients admitted to cardiac rehabilitation (CR) centers
have a cardiac resynchronization therapy (CRT) device. However, information about the …

Sympathetic Response to 1-Leg Cycling Exercise Predicts Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction

MB Badrov, T Tobushi, CF Notarius, E Keys… - Circulation: Heart …, 2024 - ahajournals.org
BACKGROUND: In heart failure, sympathetic excess and exercise intolerance impair quality
of life. In heart failure with reduced ejection fraction, exercise stimulates a reflex increase in …

Cardiovascular Autonomic Dysfunction and its association with Aortic Stenosis

L Brandon, N Connolly, M Hensey, S O'Connor… - Medical Research …, 2023 - esmed.org
Aortic stenosis remains the most common valvular abnormality that requires intervention and
is becoming more prevalent with an ageing population. Untreated symptomatic severe aortic …