Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Adipocytes are the main constituent of adipose tissue and are considered to be a corner
stone in the homeostatic control of whole body metabolism. Their primary function is to …

Obesity, a highly prevalent condition, is heterogeneous with regard to its impact on
cardiovascular disease (CVD) risk. Epidemiological observations and metabolic …

INTRODUCTION: Osteoarthritis (OA) of the knee joint is caused by genetic and hormonal
factors and by inflammation, in combination with biomechanical alterations. It is …

The scientific interest in the biology of white adipose tissue (WAT) has increased since the
discovery of leptin in 1994. The description of the product of the gene obese (ob) …

Adipose tissue contains many cell types. Among the more abundant are adipocytes,
preadipocytes, immune cells, and endothelial cells. During times of excess caloric intake …

This review summarizes recent literature about obesity, knee osteoarthritis and joint pain.
Consideration of adipocytokines, metabolic factors, and mechanical loading-metabolic factor …

OBJECTIVE: Adipose tissue is an endocrine tissue releasing adipokines suggested to be
involved in the pathogenesis of osteoarthritis (OA). Nevertheless, their relative contribution …

The understanding of the pathogenesis and optimal therapeutics for rheumatoid arthritis
(RA) has advanced remarkably over the last decade. This review highlights these key …