OpenSim: Simulating musculoskeletal dynamics and neuromuscular control to study human and animal movement

A Seth, JL Hicks, TK Uchida, A Habib… - PLoS computational …, 2018 - journals.plos.org
Movement is fundamental to human and animal life, emerging through interaction of
complex neural, muscular, and skeletal systems. Study of movement draws from and …

Bone fatigue and its implications for injuries in racehorses

S Martig, W Chen, PVS Lee… - Equine Veterinary …, 2014 - Wiley Online Library
Musculoskeletal injuries are a common cause of lost training days and wastage in
racehorses. Many bone injuries are a consequence of repeated high loading during fast …

Modern three-dimensional digital methods for studying locomotor biomechanics in tetrapods

OE Demuth, E Herbst, DT Polet… - Journal of …, 2023 - journals.biologists.com
Here, we review the modern interface of three-dimensional (3D) empirical (eg motion
capture) and theoretical (eg modelling and simulation) approaches to the study of terrestrial …

Musculoskeletal modelling of an ostrich (Struthio camelus) pelvic limb: influence of limb orientation on muscular capacity during locomotion

JR Hutchinson, JW Rankin, J Rubenson… - PeerJ, 2015 - peerj.com
We developed a three-dimensional, biomechanical computer model of the 36 major pelvic
limb muscle groups in an ostrich (Struthio camelus) to investigate muscle function in this, the …

Cartilage thickness and bone shape variations as a function of sex, height, body mass, and age in young adult knees

MTY Schneider, N Rooks, T Besier - Scientific Reports, 2022 - nature.com
The functional relationship between bone and cartilage is modulated by mechanical factors.
Scarce data exist on the relationship between bone shape and the spatial distribution of …

Subchondral bone microdamage accumulation in distal metacarpus of Thoroughbred racehorses

RC Whitton, BA Ayodele, PL Hitchens… - Equine veterinary …, 2018 - Wiley Online Library
Background Microdamage accumulation leads to subchondral bone injury and/or fracture in
racehorses. An understanding of this process is essential for developing strategies for injury …

The challenges of promoting osteogenesis in segmental bone defects and osteoporosis

AN Ball, SW Donahue, SJ Wojda… - Journal of …, 2018 - Wiley Online Library
Conventional clinical management of complex bone healing scenarios continues to result in
5–10% of fractures forming non‐unions. Additionally, the aging population and prevalence …

Training practices, speed and distances undertaken by Thoroughbred racehorses in Victoria, Australia

AV Morrice‐West, PL Hitchens… - Equine veterinary …, 2020 - Wiley Online Library
Background Musculoskeletal injuries (MSI) in racehorses are commonly due to bone fatigue,
a function of the number of cycles (strides) and the magnitude of load applied to the limb …

Thoroughbred horses in race training have lower levels of subchondral bone remodelling in highly loaded regions of the distal metacarpus compared to horses resting …

JM Holmes, M Mirams, EJ Mackie, RC Whitton - The Veterinary Journal, 2014 - Elsevier
Bone is repaired by remodelling, a process influenced by its loading environment. The aim
of this study was to investigate the effect of a change in loading environment on bone …

Advancements in Subchondral Bone Biomechanics: Insights from Computed Tomography and Micro-Computed Tomography Imaging in Equine Models

F Malekipour, RC Whitton, PVS Lee - Current Osteoporosis Reports, 2024 - Springer
Abstract Purpose of Review This review synthesizes recent advancements in understanding
subchondral bone (SCB) biomechanics using computed tomography (CT) and micro …