The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons

MD Johnson, CK Thompson… - Journal of …, 2017 - journals.physiology.org
Motoneurons are unique in being the only neurons in the CNS whose firing patterns can be
easily recorded in human subjects. This is because of the one-to-one relationship between …

Abnormal synergies and associated reactions post-hemiparetic stroke reflect muscle activation patterns of brainstem motor pathways

LM McPherson, JPA Dewald - Frontiers in neurology, 2022 - frontiersin.org
Individuals with moderate-to-severe post-stroke hemiparesis cannot control proximal and
distal joints of the arm independently because they are constrained to stereotypical …

Impact of parameter selection on estimates of motoneuron excitability using paired motor unit analysis

A Hassan, CK Thompson, F Negro… - Journal of Neural …, 2020 - iopscience.iop.org
Objective. Noninvasive estimation of motoneuron excitability in human motoneurons is
achieved through a paired motor unit analysis (ΔF) that quantifies hysteresis in the …

Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke

LM McPherson, JPA Dewald - Clinical Neurophysiology, 2019 - Elsevier
Objective The flexion and extension synergies were quantified at the paretic elbow, forearm,
wrist, and finger joints within the same group of participants for the first time. Differences in …

Essential tremor amplitude modulation by median nerve stimulation

C Reis, BS Arruda, A Pogosyan, P Brown… - Scientific Reports, 2021 - nature.com
Essential tremor is a common neurological disorder, characterised by involuntary shaking of
a limb. Patients are usually treated using medications which have limited effects on tremor …

Neuromuscular Function: High-Density Surface Electromyography

E Martinez-Valdes, F Negro - Neuromuscular Assessments of Form and …, 2023 - Springer
Surface electromyography (EMG) is a noninvasive technique that has the potential to
provide information on how the nervous system controls movement. Nevertheless …

Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings

M Bhadane, J Liu, WZ Rymer, P Zhou, S Li - Scientific reports, 2016 - nature.com
The objective was to re-evaluate the controversial reports of EMG-torque relation between
impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects …

High-density electromyography provides improved understanding of muscle function for those with amputation

U Kuruganti, A Pradhan, J Toner - Frontiers in Medical Technology, 2021 - frontiersin.org
Transtibial amputation can significantly impact an individual's quality of life including the
completion of activities of daily living. Those with lower limb amputations can harness the …

Motor unit discharge variability is increased in mild-to-moderate Parkinson's disease

JM Wilson, CK Thompson, LM McPherson… - Frontiers in …, 2020 - frontiersin.org
Individuals with Parkinson's disease (PD) demonstrate deficits in muscle activation such as
decreased amplitude and inappropriate bursting. There is evidence that some of these …

Altered neuromodulatory drive may contribute to exaggerated tonic vibration reflexes in chronic hemiparetic stroke

JG McPherson, LM McPherson… - Frontiers in Human …, 2018 - frontiersin.org
Exaggerated stretch-sensitive reflexes are a common finding in elbow flexors of the
contralesional arm in chronic hemiparetic stroke, particularly when muscles are not …