TP53, a tumor suppressor gene, plays a critical role in cell cycle control, apoptosis, and DNA
damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 …

Cancer is one of the major health burdens worldwide, and genetic polymorphisms in
individuals are closely associated with cancer susceptibility. Like in many other developing …

Background: A transversion missense polymorphism of the TP53 tumor suppressor gene at
the codon 72 codes proline instead of arginine causes an altered p53 protein expression …

Lung cancer is a problem of great concern and one of the commonest cancer diseases
worldwide and in the Republic of Kazakhstan in particular. Radon exposure is classified as …

Methods DNA was extracted from blood samples of 126 lung cancer patient and 133 healthy
controls. The MDM2 SNP309 was genotyped by polymerase chain reaction-restriction …

Lung cancer is one of the most common types of cancer in the world. Although the
mechanism of lung cancer is still unknown, a large number of studies have found a link …

The DISC1 (disrupted in sсhizophrenia 1) gene is associated with brain dysfunctions, which
are involved in a variety of mental disorders, such as schizophrenia, depression and bipolar …

Background: Tumor suppressor gene (TP53) is considered as the most frequently mutated
gene in almost all forms of human cancer. Moreover, genetic variations in the XPD gene …

Introduction ung cancer is a clinical condition characterized by the uncontrolled growth of
tissues in the lung. It results in the formation of a primary tumor and then metastasizes …

Lung cancer is one of the most common causes of cancer death worldwide. Molecular
genetic studies indicated that activation of dominant oncogenes or inactivation of tumor …