Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of
oncogenes to cancer development is mediated mainly through epigenetic priming of cancer …

B cell acute lymphoblastic leukaemia (B-ALL) is the most common form of childhood cancer.
Although treatment has advanced remarkably in the past 50 years, it still fails in~ 20% of …

Rationale: Inducing cancer differentiation is a promising approach to treat cancer. Here, we
identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and …

The initial steps of B-cell acute lymphoblastic leukemia (B-ALL) development usually pass
unnoticed in children. Several preclinical studies have shown that exposure to immune …

In principle, an oncogene is a cellular gene (proto-oncogene) that is dysfunctional, due to
mutation and fusion with another gene or overexpression. Generally, oncogenes are viewed …

PAX5, a master regulator of B cell development and maintenance, is one of the most
common targets of genetic alterations in B-cell acute lymphoblastic leukemia (B-ALL). PAX5 …

ETV6-RUNX1 is almost exclusively associated with childhood B-cell acute lymphoblastic
leukemia (B-ALL), but the consequences of ETV6-RUNX1 expression on cell lineage …

B cells face multiple restrictions on glucose and energy metabolism. Their lineage-
determining transcription factors repress glucose uptake and pentose phosphate pathway …

B cells are an integral part of the adaptive immune system and regulate innate immunity.
Derived from hematopoietic stem cells, B cells mature through a series of cell fate decisions …

Exposures to a wide repertoire of common childhood infections and strong inflammatory
responses to those infections are associated with the risk of pediatric B-cell acute …