Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

Hypothermic Oxygenated Perfusion (HOPE) of the liver can reduce the incidence of early
allograft dysfunction (EAD) and failure in extended criteria donors (ECD) grafts, although …

Acute-on-chronic liver failure (ACLF), which was described relatively recently (2013), is a
severe form of acutely decompensated cirrhosis characterised by the existence of organ …

Background & Aims Machine perfusion is increasingly being tested in clinical
transplantation. Despite this, the number of large prospective clinical trials remains limited …

A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static
cold storage is safe and reduces ischemia‐reperfusion injury‐related complications after …

Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated
machine perfusion (D-HOPE) was introduced in liver transplantation to improve …

Background & Aims Ischemia-reperfusion injury (IRI) has thus far been considered as an
inevitable component of organ transplantation, compromising outcomes, and limiting organ …

Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …