The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

As the major excitatory neurotransmitter in the mammalian central nervous system,
glutamate plays a key role in many central pathologies, including gliomas, psychiatric …

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system.
Spontaneous regression and differentiation of neuroblastoma is observed in a subset of …

Research over the last 25 years on the cell adhesion molecule L1 has revealed its pivotal
role in nervous system function. Mutations of the human L1CAM gene have been shown to …

The Repressor Element 1 Silencing Transcription factor (REST/NRSF) is a master repressor
of neuronal programs in non-neuronal lineages shown to function as a central regulator of …

The generation of dopamine (DA) neurons from stem cells holds great promise in the
treatment of Parkinson's disease and other neural disease associated with dysfunction of DA …

Neuropeptide substance P (SP) has been implicated in inflammation, pain, depression and
breast cancer cell (BCC) growth. Here, we examined the role of SP in trafficking of BCCs …

The function of the tumor suppressor RE1 silencing transcription factor (REST) is lost in
colon and small cell lung cancers and is known to induce anchorage-independent growth in …

Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate
cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and …

Breast cancer is the second leading cause of cancer death in women with increasing
incidence. Hence, finding a diagnostic factor and/or potential drug target could lead to an …