It is 3 years since our minireview on cyclins and cancer (Hunter and Pines, 1991), and in that
time the number of connections between oncogenesis and the components that regulate the …

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and
inactivates the retinoblastoma protein and promotes progression through the G1-S phase of …

Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose
regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient …

Oncogenic ras can transform most immortal rodent cells to a tumorigenic state. However,
transformation of primary cells by ras requires either a cooperating oncogene or the …

This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer
pathophysiology by identifying associations between recurrent CNAs, gene expression, and …

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and
genome instability. This review summarizes current knowledge regarding aberrations …

Publisher Summary This chapter describes techniques commonly used to study cell death
using in vitro cell culture systems. These techniques include a range of simple dye exclusion …

Increasing knowledge on the cell cycle deregulations in cancers has promoted the
introduction of phytochemicals, which can either modulate signaling pathways leading to …

PHYSICAL associations between cyclins, viral oncogenes and tumour suppressor genes
imply a central role for cyclins in growth control1, 2. Cyclin D1 was identified as a candidate …

Cyclin D1 is a component of the core cell cycle machinery. Abnormally high levels of cyclin
D1 are detected in many human cancer types. To elucidate the molecular functions of cyclin …