Pharmacological modulation of glutamate has long been considered to be of immense
therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for …

Background Activated astrocytes play important roles in chronic post-surgical pain (CPSP).
Recent studies have shown reactive astrocytes are classified into A1 and A2 phenotypes …

The response of the blood–brain barrier (BBB) following a stroke, including subarachnoid
hemorrhage (SAH), has been studied extensively. The main components of this reaction are …

(1) Background: Over the past 10 years, a number of scientific studies have demonstrated
the therapeutic potential of cannabinoid compounds present in the Cannabis Sativa and …

Aging is an inevitable natural process with time-dependent dysfunction and the occurrence
of various diseases, which impose heavy burdens on individuals, families, and society. It has …

In ischemic stroke, there is only one approved drug, tissue plasminogen activator, to be used
in clinical conditions for thrombolysis. New neuroprotective therapies for ischemic stroke are …

Brain photobiomodulation (PBM) is an innovative treatment for a variety of neurological
conditions, including cerebral ischemia. However, the capability of PBM for ischemic stroke …

The distinction between glial painful and protective pathways is unclear and the possibility to
finely modulate the system is lacking. Focusing on painful neuropathies, we studied the role …

Ischemic stroke ranks among the foremost clinical causes of mortality and disability,
instigating neuronal degeneration, fatalities, and various sequelae. While standard …

In this study, we investigated the cross-talk between mGlu1 and CB1 receptors in
modulating GABA hippocampal output in whole-cell voltage clamp recordings in rat …