The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Glycoscience research has been significantly impeded by the complex compositions of the
glycans present in biological molecules and the lack of convenient tools suitable for studying …

Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …

The influenza virus hemagglutinin (HA) and coronavirus spike (S) protein mediate virus
entry. HA and S proteins are heavily glycosylated, making them potential targets for …

Contemporary chemoenzymatic approaches can provide highly complex multi-antennary N-
linked glycans. These procedures are, however, very demanding and typically involve as …

Despite the versatility of enzyme-mediated oligosaccharide assembly, it has as a limitation
that not all glycosyl transferases or glycan-modifying enzymes are readily available to install …

The programmable one-pot oligosaccharide synthesis method was designed to enable the
rapid synthesis of a large number of oligosaccharides, using the software Optimer to search …

Carbohydrates are structurally complex but functionally important biomolecules. Therefore,
they have been challenging but attractive synthetic targets. While substantial progress has …

Asparagine (N)-linked glycosylation is one of the most common co-and post-translational
modifications of both intra-and extracellularly distributing proteins, which directly affects their …

Fucosylated carbohydrate determinants are common components of cell surface
glycoconjugates and secreted unconjugated glycans, which play pivotal roles in many …