Advanced glycation end products (AGEs), a heterogeneous group of compounds formed by
nonenzymatic glycation reactions between reducing sugars and amino acids, lipids, or DNA …

Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic
inflammation, which may lead to an increase in the synthesis of advanced glycation end …

The endothelium takes part in the regulation of numerous physiological functions and lies at
the interface of circulating blood and the vessel wall. Under physiological conditions, it is …

Encephalopathy and altered higher mental functions are common clinical complications of
acute kidney injury. Although sepsis is a major triggering factor, acute kidney injury …

Post-translational modifications (PTMs) of proteins and peptides have recently gained much
attention, as they are involved in the pathogenesis of cardiovascular disease and eventually …

Purpose Sepsis has become a global health problem with rising incidence and high
mortality, creating a substantial social and economic burden. Early diagnosis and treatment …

Previous studies reported that RAGE participated in the process of kidney fibrosis, but the
function and regulation pathway of RAGE in proximal tubular cells in this process remains …

This study aimed to explore the effect and mechanisms of rhein on sepsis-induced acute
kidney injury by injecting lipopolysaccharide (LPS) and cecal ligation and puncture (CLP) in …

Background Endothelial activation and damage occur early during sepsis, with activated
coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute …

The high mortality rates associated with acute kidney injury are mainly due to extra-renal
complications that occur following distant-organ involvement. Damage to these organs …