Epigenetic modifications serve as an extension of the information content by which the
underlying genetic code may be interpreted. These modifications mark genomic regions and …

▪ Abstract Seed development requires coordinated expression of embryo and endosperm
and has contributions from both sporophytic and male and female gametophytic genes …

A single mouse blastomere from an embryo until the 8-cell stage can generate an entire
blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains …

The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …

Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …

Steel factor (SF) and LIF (leukemia inhibitory factor) synergistically promote the proliferation
and survival of mouse primordial germ cells (PGCs), but only for a limited time period in …

Many flowering plants are polyploid, but crosses between individuals of different ploidies
produce seeds that develop abnormally and usually abort. Often, seeds from interploidy …

Only mammals have relinquished parthenogenesis, a means of producing descendants
solely from maternal germ cells. Mouse parthenogenetic embryos die by day 10 of …

Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse
haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening …

Haploids and double haploids are important resources for studying recessive traits and have
large impacts on crop breeding, but natural haploids are rare in animals. Mammalian …