The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis

J Zhao, X Wang, Z Huo, Y Chen, J Liu, Z Zhao, F Meng… - Cells, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

Medicinal cannabis and central nervous system disorders

YT Ortiz, LR McMahon, JL Wilkerson - Frontiers in pharmacology, 2022 - frontiersin.org
Cannabinoids, including those found in cannabis, have shown promise as potential
therapeutics for numerous health issues, including pathological pain and diseases that …

Oxidative stress as a therapeutic target in amyotrophic lateral sclerosis: Opportunities and limitations

HR Park, EJ Yang - Diagnostics, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou
Gehrig's disease, is characterized by a loss of the lower motor neurons in the spinal cord …

Dioxinodehydroeckol: A potential neuroprotective marine compound identified by in silico screening for the treatment and management of multiple brain disorders

F Ahmad, P Sachdeva, B Sachdeva, G Singh… - Molecular …, 2024 - Springer
Neurodegenerative disorders such as Alzheimer's disease (AD), Glioblastoma multiforme
(GBM), Amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD) are some of the …

[HTML][HTML] Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration

AM Belkozhayev, M Al-Yozbaki, A George… - Current …, 2022 - ncbi.nlm.nih.gov
There are different modalities of intercellular communication governed by cellular
homeostasis. In this review, we will explore one of these forms of communication called …

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

J Sobieraj, K Strzelecka, M Sobczak… - International Journal of …, 2024 - Taylor & Francis
Cannabinoids are compounds found in and derived from the Cannabis plants that have
become increasingly recognised as significant modulating factors of physiological …

Machine learning hypothesis-generation for patient stratification and target discovery in rare disease: our experience with Open Science in ALS

J Geraci, R Bhargava, B Qorri, P Leonchyk… - Frontiers in …, 2024 - frontiersin.org
Introduction Advances in machine learning (ML) methodologies, combined with
multidisciplinary collaborations across biological and physical sciences, has the potential to …

scAAV9-VEGF alleviates symptoms of amyotrophic lateral sclerosis (ALS) mice through regulating aromatase

Y Wang, S Sun, J Zhai, Y Liu, C Song, C Sun… - Experimental Brain …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset, chronic, progressive, and fatal
neurodegenerative disease that leads to progressive atrophy and weakness of the muscles …

[HTML][HTML] An overview about Neurological Diseases in India–A Theranostics approach

B Vellingiri - Aging and Health Research, 2023 - Elsevier
With the current global population expansion and increasing life expectancy, more people
are living in their later years, when neurological issues are most common. Both …

Esclerose Lateral Amiotrófica

F de Deus Tozani, EC de Siqueira - Revista Eletrônica Acervo …, 2023 - acervomais.com.br
Objetivo: Analisar as características da Esclerose Lateral Amiotrófica (ELA). Revisão
bibliográfica: A ELA, também conhecida como doença do neurônio motor, é uma doença …