Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease

SA Polyzos, ID Vachliotis, CS Mantzoros - Metabolism, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD), sarcopenia and sarcopenic obesity (SO) are
highly prevalent conditions that may coexist, especially in the aging population, without any …

[HTML][HTML] Therapeutic application of natural compounds for skeletal muscle-associated metabolic disorders: A review on diabetes perspective

K Ahmad, S Shaikh, JH Lim, SS Ahmad… - Biomedicine & …, 2023 - Elsevier
Skeletal muscle (SM) plays a vital role in energy and glucose metabolism by regulating
insulin sensitivity, glucose uptake, and blood glucose homeostasis. Impaired SM …

Crosstalk between autophagy and insulin resistance: Evidence from different tissues

A Sadeghi, M Niknam… - European Journal of …, 2023 - Springer
Insulin is a critical hormone that promotes energy storage in various tissues, as well as
anabolic functions. Insulin resistance significantly reduces these responses, resulting in …

Sarcopenia: still in relative definition-penia and severe treatment-penia

SA Polyzos, CS Mantzoros - Metabolism, 2023 - Elsevier
Sarcopenia derives from the Greek words “sarx”(ie, flesh) and “penia”(ie, deficiency), and
denotes the decline in the quantity (ie, number of motor units) and quality (atrophy of muscle …

GABA prevents age-related sarcopenic obesity in mice with high-fat-diet-induced obesity

H Jin, HJ Oh, BY Lee - Cells, 2023 - mdpi.com
Sarcopenic obesity is characterized by concurrent obesity and muscle wasting (sarcopenia)
and is common in the elderly. Sarcopenic obesity has steadily increased as the aging …

Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein …

C Deng, C Lu, K Wang, M Chang, Y Shen… - Frontiers in …, 2024 - frontiersin.org
Aim: Diabetic sarcopenia leads to disability and seriously affects the quality of life. Currently,
there are no effective therapeutic strategies for diabetic sarcopenia. Our previous studies …

Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Y Zheng, J Feng, Y Yu, M Ling, X Wang - Archives of Pharmacal Research, 2024 - Springer
Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses
significant health risks in older adults worldwide. Both pharmacological and non …

[HTML][HTML] Sarcopenic obesity and osteoporosis: Research progress and hot spots

S Fan, Y Cai, Y Wei, J Yang, J Gao, Y Yang - Experimental Gerontology, 2024 - Elsevier
Sarcopenic obesity (SO) and osteoporosis (OP) are associated with aging and obesity. The
pathogenesis of SO is complex, including glucolipid and skeletal muscle metabolic …

Control of muscle satellite cell function by specific exercise‐induced cytokines and their applications in muscle maintenance

Q Guo, Q Luo, G Song - Journal of Cachexia, Sarcopenia and …, 2024 - Wiley Online Library
Exercise is recognized to play an observable role in improving human health, especially in
promoting muscle hypertrophy and intervening in muscle mass loss‐related diseases …