Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and
asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical …

Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …

Success with B cell depletion using rituximab has proven the concept that B lineage cells
represent a valid target for the treatment of autoimmune diseases, and has promoted the …

The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …

Antibodies produced in response to a foreign antigen are characterized by polyclonality, not
only in the diverse epitopes to which their variable domains bind but also in the various …

Human IgG is the most abundant glycoprotein in serum and is crucial for protective
immunity. In addition to conserved IgG Fc glycans,∼ 15–25% of serum IgG contains glycans …

Review on mannose receptor as an endocytic receptor in antigen delivery that is co-
expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a …

IgG molecules exert both pro-and antiinflammatory effector functions based on the
composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains …