[HTML][HTML] Machine learning in clinical trials: a primer with applications to neurology

MI Miller, LC Shih, VB Kolachalama - Neurotherapeutics, 2023 - Elsevier
We reviewed foundational concepts in artificial intelligence (AI) and machine learning (ML)
and discussed ways in which these methodologies may be employed to enhance progress …

Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist

WT Kerr, KN McFarlane - Current Neurology and Neuroscience Reports, 2023 - Springer
Abstract Purpose of Review Machine Learning (ML) and Artificial Intelligence (AI) are data-
driven techniques to translate raw data into applicable and interpretable insights that can …

Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries

DM Goldenholz, MB Westover - Epilepsia, 2023 - Wiley Online Library
Objective A realistic seizure diary simulator is currently unavailable for many research
needs, including clinical trial analysis and evaluation of seizure detection and seizure …

Increasing challenges to trial recruitment and conduct over time

WT Kerr, AS Reddy, SH Seo, N Kok, WC Stacey… - …, 2023 - Wiley Online Library
Objective This study was undertaken to evaluate how the challenges in the recruitment and
retention of participants in clinical trials for focal onset epilepsy have changed over time …

Time to exceed pre‐randomization monthly seizure count for perampanel in participants with primary generalized tonic–clonic seizures: A potential clinical end point

WT Kerr, C Brandt, LY Ngo, A Patten, JY Cheng… - …, 2022 - Wiley Online Library
Objective To evaluate the exploratory time to exceed pre‐randomization seizure count (T‐
PSC) in the determination of efficacy of adjunctive perampanel in participants with primary …

Increasing transparency in machine learning through bootstrap simulation and shapely additive explanations

AA Huang, SY Huang - PLoS One, 2023 - journals.plos.org
Machine learning methods are widely used within the medical field. However, the reliability
and efficacy of these models is difficult to assess, making it difficult for researchers to identify …

Minimum clinical utility standards for wearable seizure detectors: A simulation study

DM Goldenholz, PJ Karoly, PF Viana, E Nurse… - …, 2024 - Wiley Online Library
Objective Epilepsy management employs self‐reported seizure diaries, despite evidence of
seizure underreporting. Wearable and implantable seizure detection devices are now …

Prescriptive method for optimizing cost of data collection and annotation in machine learning of clinical ultrasound

A Lawley, R Hampson, K Worrall… - 2023 45th Annual …, 2023 - ieeexplore.ieee.org
Machine learning in medical ultrasound faces a major challenge: the prohibitive costs of
producing and annotating clinical data. Optimizing the data collection and annotation will …