Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe,
efficient, and clinically relevant delivery modalities,. Here we demonstrate the safety and …

Hearing loss is the most common sensory disorder. While gene therapy has emerged as a
promising treatment of inherited diseases like hearing loss, it is dependent on the …

The cochlea uses two types of mechanosensory cell to detect sounds. A single row of inner
hair cells (IHCs) synapse onto neurons to transmit sensory information to the brain, and …

Organoids have certain cellular composition and physiological features in common with real
organs, making them promising models of organ formation, function, and diseases …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high
percentage of the population. Currently, no approach exists to obtain large numbers of …

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …