Carbon–Carbon Bond Cleavage for Late-Stage Functionalization
YF Liang, M Bilal, LY Tang, TZ Wang, YQ Guan… - Chemical …, 2023 - ACS Publications
Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …
The expanding structural variety among bacteriocins from Gram-positive bacteria
JZ Acedo, S Chiorean, JC Vederas… - FEMS microbiology …, 2018 - academic.oup.com
Bacteria use various strategies to compete in an ecological niche, including the production
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …
YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function
BJ Burkhart, CJ Schwalen, G Mann, JH Naismith… - Chemical …, 2017 - ACS Publications
With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …
[HTML][HTML] Introduction to thiopeptides: biological activity, biosynthesis, and strategies for functional reprogramming
AA Vinogradov, H Suga - Cell Chemical Biology, 2020 - cell.com
Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …
Chimeric leader peptides for the generation of non-natural hybrid RiPP products
BJ Burkhart, N Kakkar, GA Hudson… - ACS Central …, 2017 - ACS Publications
Combining biosynthetic enzymes from multiple pathways is an attractive approach for
producing molecules with desired structural features; however, progress has been …
producing molecules with desired structural features; however, progress has been …
Muscarine, imidazole, oxazole and thiazole alkaloids
Z Jin - Natural product reports, 2016 - pubs.rsc.org
Covering: July 2012 to June 2015. Previous review: Nat. Prod. Rep., 2013, 30, 869–915 The
structurally diverse imidazole-, oxazole-, and thiazole-containing secondary metabolites are …
structurally diverse imidazole-, oxazole-, and thiazole-containing secondary metabolites are …
Dehydroamino acids: Chemical multi-tools for late-stage diversification
JW Bogart, AA Bowers - Organic & biomolecular chemistry, 2019 - pubs.rsc.org
α, β-Dehydroamino acids (dhAAs) are noncanonical amino acids that are found in a wide
array of natural products and can be easily installed into peptides and proteins. dhAAs …
array of natural products and can be easily installed into peptides and proteins. dhAAs …
Chemoenzymatic synthesis of thiazolyl peptide natural products featuring an enzyme-catalyzed formal [4+ 2] cycloaddition
WJ Wever, JW Bogart, JA Baccile… - Journal of the …, 2015 - ACS Publications
Thiocillins from Bacillus cereus ATCC 14579 are members of the well-known thiazolyl
peptide class of natural product antibiotics, the biosynthesis of which has recently been …
peptide class of natural product antibiotics, the biosynthesis of which has recently been …
[HTML][HTML] A general method for site-selective Csp 3–S bond formation via cooperative catalysis
Y Qin, Y Han, Y Tang, J Wei, M Yang - Chemical Science, 2020 - pubs.rsc.org
Herein, we report a copper-catalysed site-selective thiolation of Csp3–H bonds of aliphatic
amines. The method features a broad substrate scope and good functional group …
amines. The method features a broad substrate scope and good functional group …
The application of sulfur-containing peptides in drug discovery
J Zhao, X Jiang - Chinese Chemical Letters, 2018 - Elsevier
In recent decades, peptides as potential drugs were more and more explored with the
development of non-oral medicine. There into, sulfur-containing peptide is one of the most …
development of non-oral medicine. There into, sulfur-containing peptide is one of the most …