Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …

Bacteria use various strategies to compete in an ecological niche, including the production
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …

With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Combining biosynthetic enzymes from multiple pathways is an attractive approach for
producing molecules with desired structural features; however, progress has been …

Covering: July 2012 to June 2015. Previous review: Nat. Prod. Rep., 2013, 30, 869–915 The
structurally diverse imidazole-, oxazole-, and thiazole-containing secondary metabolites are …

α, β-Dehydroamino acids (dhAAs) are noncanonical amino acids that are found in a wide
array of natural products and can be easily installed into peptides and proteins. dhAAs …

Thiocillins from Bacillus cereus ATCC 14579 are members of the well-known thiazolyl
peptide class of natural product antibiotics, the biosynthesis of which has recently been …

Herein, we report a copper-catalysed site-selective thiolation of Csp3–H bonds of aliphatic
amines. The method features a broad substrate scope and good functional group …

In recent decades, peptides as potential drugs were more and more explored with the
development of non-oral medicine. There into, sulfur-containing peptide is one of the most …