[HTML][HTML] Understanding interleukin 11 as a disease gene and therapeutic target
SA Cook - Biochemical journal, 2023 - portlandpress.com
Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially
thought to be a haematopoietic and cytoprotective factor, more recent data show instead that …
thought to be a haematopoietic and cytoprotective factor, more recent data show instead that …
Emerging therapeutic targets in systemic sclerosis
S O'Reilly - Journal of Molecular Medicine, 2024 - Springer
Systemic sclerosis is an autoimmune connective tissue disease which is characterised by
vascular perturbations, inflammation, and fibrosis. Although huge progress recently into the …
vascular perturbations, inflammation, and fibrosis. Although huge progress recently into the …
Interleukin 11 therapy causes acute left ventricular dysfunction
Abstract Aims Interleukin 11 (IL11) was initially thought important for platelet production,
which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 …
which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 …
Harnessing the regenerative potential of interleukin11 to enhance heart repair
Balancing between regenerative processes and fibrosis is crucial for heart repair, yet
strategies regulating this balance remain a barrier to developing therapies. The role of …
strategies regulating this balance remain a barrier to developing therapies. The role of …
The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review
YLL Braga, JR do Carmo Neto, PIR Franco… - Journal of …, 2024 - mdpi.com
Fibrosis is one of the main factors that impair the function of many organs. In the heart,
fibrosis leads to contractile dysfunction and arrhythmias, which are important in the …
fibrosis leads to contractile dysfunction and arrhythmias, which are important in the …
Stellate ganglion, inflammation, and arrhythmias: a new perspective on neuroimmune regulation
Q Lei, Z Jiang, Y Shao, X Liu, X Li - Frontiers in Cardiovascular …, 2024 - frontiersin.org
Current research on the stellate ganglion (SG) has shifted from merely understanding its role
as a collection of neurons to recognizing its importance in immune regulation. As part of the …
as a collection of neurons to recognizing its importance in immune regulation. As part of the …
Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered
Abstract Background Interleukin 11 (IL11) was initially thought important for platelet
production, which led to recombinant IL11 being developed as a drug to treat …
production, which led to recombinant IL11 being developed as a drug to treat …
Potential Biomarkers in Myocardial Fibrosis: A Bioinformatic Analysis
W Cheng-Mei, G Luo, P Liu, W Ren… - Arquivos Brasileiros de …, 2024 - SciELO Brasil
SciELO - Brasil - Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise
Bioinformática Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise …
Bioinformática Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise …
[HTML][HTML] IL-11 Expression in Systemic Sclerosis Is Dependent on Caspase-1 Activity but Does Not Increase Collagen Deposition
CM McFalls, LM Connolly, AG Fustakgi, CM Artlett - Rheumato, 2024 - mdpi.com
Background: Interleukin-11 (IL-11) is increased in patients with systemic sclerosis (SSc) and
is thought to play a role in fibrosis. Many studies have reported decreased fibrosis when IL …
is thought to play a role in fibrosis. Many studies have reported decreased fibrosis when IL …
Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise Bioinformática
W Cheng-Mei, G Luo, P Liu, W Ren… - Arquivos Brasileiros de …, 2024 - SciELO Brasil
Fundamento A fibrose miocárdica (FM) ocorre durante o início ea progressão da doença
cardiovascular, eo diagnóstico precoce da FM é benéfico para melhorar a função cardíaca …
cardiovascular, eo diagnóstico precoce da FM é benéfico para melhorar a função cardíaca …