[HTML][HTML] Understanding interleukin 11 as a disease gene and therapeutic target

SA Cook - Biochemical journal, 2023 - portlandpress.com
Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially
thought to be a haematopoietic and cytoprotective factor, more recent data show instead that …

Emerging therapeutic targets in systemic sclerosis

S O'Reilly - Journal of Molecular Medicine, 2024 - Springer
Systemic sclerosis is an autoimmune connective tissue disease which is characterised by
vascular perturbations, inflammation, and fibrosis. Although huge progress recently into the …

Interleukin 11 therapy causes acute left ventricular dysfunction

M Sweeney, K O'Fee, C Villanueva-Hayes… - Cardiovascular …, 2024 - academic.oup.com
Abstract Aims Interleukin 11 (IL11) was initially thought important for platelet production,
which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 …

Harnessing the regenerative potential of interleukin11 to enhance heart repair

K Shin, A Rodriguez-Parks, C Kim, IM Silaban… - Nature …, 2024 - nature.com
Balancing between regenerative processes and fibrosis is crucial for heart repair, yet
strategies regulating this balance remain a barrier to developing therapies. The role of …

The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review

YLL Braga, JR do Carmo Neto, PIR Franco… - Journal of …, 2024 - mdpi.com
Fibrosis is one of the main factors that impair the function of many organs. In the heart,
fibrosis leads to contractile dysfunction and arrhythmias, which are important in the …

Stellate ganglion, inflammation, and arrhythmias: a new perspective on neuroimmune regulation

Q Lei, Z Jiang, Y Shao, X Liu, X Li - Frontiers in Cardiovascular …, 2024 - frontiersin.org
Current research on the stellate ganglion (SG) has shifted from merely understanding its role
as a collection of neurons to recognizing its importance in immune regulation. As part of the …

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

M Sweeney, K O'Fee, C Villanueva-Hayes, E Rahman… - bioRxiv, 2023 - biorxiv.org
Abstract Background Interleukin 11 (IL11) was initially thought important for platelet
production, which led to recombinant IL11 being developed as a drug to treat …

Potential Biomarkers in Myocardial Fibrosis: A Bioinformatic Analysis

W Cheng-Mei, G Luo, P Liu, W Ren… - Arquivos Brasileiros de …, 2024 - SciELO Brasil
SciELO - Brasil - Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise
Bioinformática Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise …

[HTML][HTML] IL-11 Expression in Systemic Sclerosis Is Dependent on Caspase-1 Activity but Does Not Increase Collagen Deposition

CM McFalls, LM Connolly, AG Fustakgi, CM Artlett - Rheumato, 2024 - mdpi.com
Background: Interleukin-11 (IL-11) is increased in patients with systemic sclerosis (SSc) and
is thought to play a role in fibrosis. Many studies have reported decreased fibrosis when IL …

Biomarcadores Potenciais na Fibrose Miocárdica: Uma Análise Bioinformática

W Cheng-Mei, G Luo, P Liu, W Ren… - Arquivos Brasileiros de …, 2024 - SciELO Brasil
Fundamento A fibrose miocárdica (FM) ocorre durante o início ea progressão da doença
cardiovascular, eo diagnóstico precoce da FM é benéfico para melhorar a função cardíaca …