CD56bright natural killer (NK) cells: an important NK cell subset

A Poli, T Michel, M Thérésine, E Andrès… - …, 2009 - Wiley Online Library
Human natural killer (NK) cells can be subdivided into different populations based on the
relative expression of the surface markers CD16 and CD56. The two major subsets are …

Utilizing cytokines to function‐enable human NK cells for the immunotherapy of cancer

R Romee, JW Leong, TA Fehniger - Scientifica, 2014 - Wiley Online Library
Natural killer (NK) cells are innate lymphoid cells important for host defense against
pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals …

Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B

ETTL Tjwa, GW van Oord, JP Hegmans… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Natural killer (NK) cells play a major role in anti-viral immunity as
first line defense and regulation of virus-specific T cell responses. This study aimed to …

Natural killer (NK) cells in antibacterial innate immunity: angels or devils?

F Souza-Fonseca-Guimaraes, M Adib-Conquy… - Molecular …, 2012 - Springer
Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells
and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their …

Cancer immunotherapy

CN Baxevanis, SA Perez… - Critical reviews in clinical …, 2009 - Taylor & Francis
Recent scientific advances have expanded our understanding of the immune system and its
response to malignant cells. The clinical goal of tumour immunotherapy is to provide either …

Characterization and comparison of 'Standard'and 'young'Tumour‐Infiltrating lymphocytes for adoptive cell therapy at a Danish Translational research institution

M Donia, N Junker, E Ellebaek… - Scandinavian …, 2012 - Wiley Online Library
Adoptive cell therapy (ACT) with ex vivo expanded tumour‐infiltrating lymphocytes (TILs) in
combination with IL‐2 is an effective treatment for metastatic melanoma. Modified protocols …

Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

A Vargas-Hernández, EM Mace, O Zimmerman… - Journal of Allergy and …, 2018 - Elsevier
Background Natural killer (NK) cells are critical innate effector cells whose development is
dependent on the Janus kinase–signal transducer and activator of transcription (STAT) …

NK cells and cancer immunoediting

C Guillerey, MJ Smyth - Natural killer cells, 2016 - Springer
Natural killer (NK) cells are innate lymphoid cells (ILC) known for their ability to recognize
and rapidly eliminate infected or transformed cells. Consequently, NK cells are fundamental …

Clinically feasible approaches to potentiating cancer cell-based immunotherapies

VI Seledtsov, AG Goncharov… - Human vaccines & …, 2015 - Taylor & Francis
The immune system exerts both tumor-destructive and tumor-protective functions. Mature
dendritic cells (DCs), classically activated macrophages (M1), granulocytes, B lymphocytes …

The innate immune system and cardiovascular disease in ESKD: monocytes and natural killer cells

E Dounousi, A Duni, KK Naka… - Current Vascular …, 2021 - ingentaconnect.com
Adverse innate immune responses have been implicated in several disease processes,
including cardiovascular disease (CVD) and chronic kidney disease (CKD). The monocyte …