Staphylococcus aureus is a major bacterial pathogen that causes disease worldwide. The
emergence of strains that are resistant to commonly used antibiotics and the failure of …

Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful
infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore …

Staphylococcus aureus can produce up to five different bi-component cytotoxins: two
gamma-hemolysins HlgAB and HlgCB, and leukocidins SF-PV (Panton Valentine …

Macrocycle-to-macrocycle interconversions are of interest because they can allow access to
a variety of structures. However, reversible interconversion between different sized …

Leukocidin ED (LukED) is a pore-forming toxin produced by Staphylococcus aureus, which
lyses host cells and promotes virulence of the bacteria. LukED enables S. aureus to acquire …

Staphylococcus aureus (SA) leukocidin ED (LukED) belongs to a family of bicomponent
pore forming toxins that play important roles in SA immune evasion and nutrient acquisition …

Staphylococcal leukotoxins are a family of β-barrel, bicomponent, pore-forming toxins with
membrane-damaging functions. These bacterial exotoxins share sequence and structural …

Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus
aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor …

Abstract Staphylococcus aureus Panton-Valentine leukocidin is a pore-forming toxin
targeting the human C5a receptor (hC5aR), enabling this pathogen to battle the immune …

In the Gram-positive pathogen Staphylococcus aureus, pore-forming toxins (PFTs), such as
leukocidins and hemolysins, play prominent roles in staphylococcal pathogenesis by killing …