Tamoxifen (TAM) resistance constitutes a challenge in managing estrogen receptor (ER) α+
breast cancer patients. G-protein-coupled estrogen receptor (GPR30/GPER), which …

Cancer‐associated fibroblasts (CAFs) are crucial component of tumor microenvironment
(TME) which undergo significant phenotypic changes and metabolic reprogramming …

Bladder cancer (BC) is the most common urinary system malignancy worldwide. However,
the molecular mechanisms underlying its progression remain largely unexplored …

Background Stromal reaction is an important prognostic factor in several cancers, and the
presence of myxoid change was assessed as a poor prognostic factor in colorectal cancer …

Background In colorectal cancer, hPG80 (progastrin) is released from tumor cells, promotes
cancer stem cells (CSC) self-renewal and is detected in the blood of patients. Because the …

The crosstalk between tumor and stroma plays a critical role in cancer metastasis. However,
the function of miR-10a-5p on liver fibroblasts in the metastatic microenvironment of colon …

The hallmark of epithelial-to-mesenchymal transition (EMT) is the switch from epithelial
cadherin (E-cadherin) to neural cadherin (N-cadherin), allowing melanoma cells to form a …

Cell-based therapies cure some hematologic malignancies, although little information exists
on solid cancer cell responses. The study objective was to test the hypothesis that …

Fibroblasts are actively involved in the formation of granulation tissue and/or tumor stroma.
These cells possess the potential to differentiate into myofibroblasts acquiring a highly …

Introduction: Myofibroblasts are the main stromal components that constitute the
desmoplastic reaction of host cells to inductive stimuli exerted by tumor cells. The purpose of …